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Highly sensitive determination of atropine using cobalt oxide nanostructures: Influence of functional groups on the signal sensitivity
University of Bristol, England; University of Sindh, Pakistan.
King Saud University, Saudi Arabia; Sohag University, Egypt.
University of Bristol, England.
University of Sindh, Pakistan.
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2016 (English)In: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 948, 30-39 p.Article in journal (Refereed) Published
Abstract [en]

This study describes sensitive determination of atropine using glassy carbon electrodes (GCE) modified with Co3O4 nanostructures. The as-synthesised nanostructures were grown using cysteine (CYS), glutathione (GSH) and histidine (HYS) as effective templates under hydrothermal action. The obtained morphologies revealed interesting structural features, including both cavity-based and flower-shaped structures. The as-synthesised morphologies were noted to actively participate in electro-catalysis of atropine (AT) drug where GSH-assisted structures exhibited the best signal response in terms of current density and over-potential value. The study also discusses the influence of functional groups on the signal sensitivity of atropine electro-oxidation. The functionalisation was carried with the amino acids originally used as effective templates for the growth of Co3O4 nanostructures. The highest increment was obtained when GSH was used as the surface functionalising agent. The GSH-functionalised Co3O4-modified electrode was utilised for the electro-chemical sensing of AT in a concentration range of 0.01 -0.46 mu M. The developed sensor exhibited excellent working linearity (R-2 = 0.999) and signal sensitivity up to 0.001 mu M of AT. The noted high sensitivity of the sensor is associated with the synergy of superb surface architectures and favourable interaction facilitating the electron transfer kinetics for the electro-catalytic oxidation of AT. Significantly, the developed sensor demonstrated excellent working capability when used for AT detection in human urine samples with strong anti-interference potential against common co-existing species, such as glucose, fructose, cysteine, uric acid, dopamine and ascorbic acid. (C) 2016 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2016. Vol. 948, 30-39 p.
Keyword [en]
Amino acids; Co3O4 nanostructures; Atropine; Functionalised nanomaterial
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-133101DOI: 10.1016/j.aca.2016.11.015ISI: 000388109300004PubMedID: 27871607Scopus ID: 2-s2.0-84995665637OAI: oai:DiVA.org:liu-133101DiVA: diva2:1055300
Note

Funding Agencies|Higher Education Commission, Islamabad, Pakistan; Deanship of Scientific Research at King Saud University [PRG-1437-30]

Available from: 2016-12-12 Created: 2016-12-09 Last updated: 2016-12-21

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