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Multi-centre validation of an automatic algorithm for fast 4D myocardial segmentation in cine CMR datasets
Katholieke University of Leuven, Belgium; ICVS 3Bs PT Govt Associate Lab, Portugal; University of Minho, Portugal.
ICVS 3Bs PT Govt Associate Lab, Portugal; DIGARC Polytech Institute Cavado and Ave, Portugal.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0003-1395-8296
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2016 (English)In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 17, no 10, 1118-1127 p.Article in journal (Refereed) Published
Abstract [en]

Aims Quantitative analysis of cine cardiac magnetic resonance (CMR) images for the assessment of global left ventricular morphology and function remains a routine task in clinical cardiology practice. To date, this process requires user interaction and therefore prolongs the examination (i.e. cost) and introduces observer variability. In this study, we sought to validate the feasibility, accuracy, and time efficiency of a novel framework for automatic quantification of left ventricular global function in a clinical setting. Methods and results Analyses of 318 CMR studies, acquired at the enrolment of patients in a multi-centre imaging trial (DOPPLER-CIP), were performed automatically, as well as manually. For comparative purposes, intra-and inter-observer variability was also assessed in a subset of patients. The extracted morphological and functional parameters were compared between both analyses, and time efficiency was evaluated. The automatic analysis was feasible in 95% of the cases (302/318) and showed a good agreement with manually derived reference measurements, with small biases and narrow limits of agreement particularly for end-diastolic volume (-4.08 +/- 8.98 mL), end-systolic volume (1.18 +/- 9.74 mL), and ejection fraction (-1.53 +/- 4.93%). These results were comparable with the agreement between two independent observers. A complete automatic analysis took 5.61 +/- 1.22 s, which is nearly 150 times faster than manual contouring (14 +/- 2 min, P amp;lt; 0.05). Conclusion The proposed automatic framework provides a fast, robust, and accurate quantification of relevant left ventricular clinical indices in real-world cine CMR images.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2016. Vol. 17, no 10, 1118-1127 p.
Keyword [en]
cardiac cine MRI; left ventricular quantification; clinical validation; automatic segmentation; fast image processing
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-133278DOI: 10.1093/ehjci/jev247ISI: 000388369300006PubMedID: 26494877OAI: oai:DiVA.org:liu-133278DiVA: diva2:1057469
Note

Funding Agencies|FCT-Fundacao para a Ciencia e a Tecnologia, Portugal [SFRH/BD/93443/2013]; EU [223615]

Available from: 2016-12-18 Created: 2016-12-15 Last updated: 2016-12-18

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Engvall, JanEbbers, Tino
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Clinical Physiology in LinköpingCenter for Medical Image Science and Visualization (CMIV)
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European Heart Journal Cardiovascular Imaging
Radiology, Nuclear Medicine and Medical Imaging

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CiteExportLink to record
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