High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented mothers are related to less immunoglobulin E-associated disease in infancyShow others and affiliations
2016 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 105, no 11, p. 1337-1347Article in journal (Refereed) Published
Abstract [en]
Aim: We previously reported a protective effect of maternal omega-3 fatty acid supplements on the development of immunoglobulin E (IgE)-associated disease in infancy. This study assessed omega-3 long-chain polyunsaturated fatty acids (LCPUFA) in maternal milk in relation to omega-3 LCPUFA supplementation and the development of allergic disease in their infants. Methods: This study randomised 95 pregnant women at risk of having an allergic infant, to daily supplements of 2.6 g omega-3 LCPUFA or a placebo of 2.7 g soya bean oil from gestational week 25 until 3 months of lactation. Breast milk samples were collected as colostrum, at one and 3 months. Milk fatty acids were related to allergic outcome in the infants at 24 months. Results: Omega-3 milk fatty acids were higher in women who received omega-3 supplements than the placebo group (p amp;lt; 0.01). Higher proportions of milk eicosapentaenoic acid and docosahexaenoic acid and a lower arachidonic/ eicosapentaenoic acid ratio were associated with an absence of IgE-associated disease in the infants. None of the children developed IgE-associated atopic eczema above a level of 0.83 mol% eicosapentaenoic acid in colostrum. [Correction added on 7 July 2016, after online publication: In the preceding sentence, the correct word should be " above" instead of " below" and this has been amended in this current version.] Conclusion: High omega-3 LCPUFA milk levels in mothers who received omega-3 LCPUFA supplements were related to fewer allergies in their children.
Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 105, no 11, p. 1337-1347
Keywords [en]
Allergic disease; Breastfeeding; Immunoglobulin E; Omega-3; Pregnancy
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-133269DOI: 10.1111/apa.13395ISI: 000387792200021PubMedID: 26970335OAI: oai:DiVA.org:liu-133269DiVA, id: diva2:1057477
Note
Funding Agencies|Ekhaga Foundation; Swedish Research Council Formas; Research Council for the South-East of Sweden; Ostergotland County Council; Swedish Asthma and Allergy Research Foundation; Swedish Research Council; Trygg Hansa Research Foundation
2016-12-182016-12-152021-02-25Bibliographically approved