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High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented mothers are related to less immunoglobulin E-associated disease in infancy
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. AstraZeneca, Sweden.
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2016 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 105, no 11, 1337-1347 p.Article in journal (Refereed) Published
Abstract [en]

Aim: We previously reported a protective effect of maternal omega-3 fatty acid supplements on the development of immunoglobulin E (IgE)-associated disease in infancy. This study assessed omega-3 long-chain polyunsaturated fatty acids (LCPUFA) in maternal milk in relation to omega-3 LCPUFA supplementation and the development of allergic disease in their infants. Methods: This study randomised 95 pregnant women at risk of having an allergic infant, to daily supplements of 2.6 g omega-3 LCPUFA or a placebo of 2.7 g soya bean oil from gestational week 25 until 3 months of lactation. Breast milk samples were collected as colostrum, at one and 3 months. Milk fatty acids were related to allergic outcome in the infants at 24 months. Results: Omega-3 milk fatty acids were higher in women who received omega-3 supplements than the placebo group (p amp;lt; 0.01). Higher proportions of milk eicosapentaenoic acid and docosahexaenoic acid and a lower arachidonic/ eicosapentaenoic acid ratio were associated with an absence of IgE-associated disease in the infants. None of the children developed IgE-associated atopic eczema above a level of 0.83 mol% eicosapentaenoic acid in colostrum. [Correction added on 7 July 2016, after online publication: In the preceding sentence, the correct word should be " above" instead of " below" and this has been amended in this current version.] Conclusion: High omega-3 LCPUFA milk levels in mothers who received omega-3 LCPUFA supplements were related to fewer allergies in their children.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 105, no 11, 1337-1347 p.
Keyword [en]
Allergic disease; Breastfeeding; Immunoglobulin E; Omega-3; Pregnancy
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-133269DOI: 10.1111/apa.13395ISI: 000387792200021PubMedID: 26970335OAI: oai:DiVA.org:liu-133269DiVA: diva2:1057477
Note

Funding Agencies|Ekhaga Foundation; Swedish Research Council Formas; Research Council for the South-East of Sweden; Ostergotland County Council; Swedish Asthma and Allergy Research Foundation; Swedish Research Council; Trygg Hansa Research Foundation

Available from: 2016-12-18 Created: 2016-12-15 Last updated: 2017-03-30Bibliographically approved

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Warstedt, KristinaFuruhjelm, CatrinFälth-Magnusson, KarinFagerås Böttcher, MalinDuchén, Karel
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Division of Clinical SciencesFaculty of Medicine and Health SciencesDepartment of Paediatrics in Linköping
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CiteExportLink to record
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