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Hyperelastic Nanocellulose-Reinforced Hydrogel of High Water Content for Ophthalmic Applications
Uppsala University, Sweden.
Uppsala University, Sweden.
Uppsala University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
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2016 (English)In: ACS BIOMATERIALS SCIENCE and ENGINEERING, ISSN 2373-9878, Vol. 2, no 11, 2072-2079 p.Article in journal (Refereed) Published
Abstract [en]

A nanocellulose-reinforced poly(vinyl alcohol) hydrogel material of exceptionally high water content for ophthalmic applications is presented (amp;gt;90 wt %), which also features a hitherto unprecedented combination of optical, mechanical, viscoelastic, oxygen permeability, and biocompatibility properties. The hydrogel combines the desired softness with remarkable strain-dependent mechanical strength and thereby demonstrates hyperelastic, rubber-like mechanical properties. The observed unusual mechanical behavior is due to both high water content and the combination of relatively stiff cellulose nanowhiskers entangled in a soft polymer matrix of poly(vinyl alcohol) (PVA), thus mimicking the structural characteristics of the corneas main constituents, i.e., water and collagen.

Place, publisher, year, edition, pages
AMER CHEMICAL SOC , 2016. Vol. 2, no 11, 2072-2079 p.
Keyword [en]
ophthalmic prosthesis; contact lens; cellulose nanocrystals; biocompatibility; poly(vinyl alcohol)
National Category
Medical Materials
Identifiers
URN: urn:nbn:se:liu:diva-133268DOI: 10.1021/acsbiomaterials.6b00484ISI: 000388161200027OAI: oai:DiVA.org:liu-133268DiVA: diva2:1057478
Note

Funding Agencies|Wallenberg Wood Science Center; Knut and Alice Wallenberg Foundation; Vinnova grant [2013-04645]

Available from: 2016-12-18 Created: 2016-12-15 Last updated: 2016-12-18

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Liszka, AnetaBuznyk, OleksiyGriffith, May
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