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Increased fMRI Sensitivity at Equal Data Burden Using Averaged Shifted Echo Acquisition
Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-2167-2450
2016 (English)In: Frontiers in Neuroscience, ISSN 1662-4548, E-ISSN 1662-453X, Vol. 10, article id 544Article in journal (Refereed) Published
Abstract [en]

There is growing evidence as to the benefits of collecting BOLD fMRI data with increased sampling rates. However, many of the newly developed acquisition techniques developed to collect BOLD data with ultra-short TRs require hardware, software, and non-standard analytic pipelines that may not be accessible to all researchers. We propose to incorporate the method of shifted echo into a standard multi-slice, gradient echo EPI sequence to achieve a higher sampling rate with a TR of amp;lt; 1 s with acceptable spatial resolution. We further propose to incorporate temporal averaging of consecutively acquired EPI volumes to both ameliorate the reduced temporal signal-to-noise inherent in ultra-fast EPI sequences and reduce the data burden. BOLD data were collected from 11 healthy subjects performing a simple, event-related visual-motor task with four different EPI sequences: (1) reference EP/sequence with TR = 1440 ms, (2) shifted echo EP/sequence with TR = 700 ms, (3) shifted echo EPI sequence with every two consecutively acquired EPI volumes averaged and effective TR = 1400 ms, and (4) shifted echo EPI sequence with every four consecutively acquired EPI volumes averaged and effective TR = 2800 ms. Both the temporally averaged sequences exhibited increased temporal signal-to-noise over the shifted echo EPI sequence. The shifted echo sequence with every two EPI volumes averaged also had significantly increased BOLD signal change compared with the other three sequences, while the shifted echo sequence with every four EPI volumes averaged had significantly decreased BOLD signal change compared with the other three sequences. The results indicated that incorporating the method of shifted echo into a standard multi-slice EPI sequence is a viable method for achieving increased sampling rate for collecting event-related BOLD data. Further, consecutively averaging every two consecutively acquired EPI volumes significantly increased the measured BOLD signal change and the subsequently calculated activation map statistics.

Place, publisher, year, edition, pages
FRONTIERS MEDIA SA , 2016. Vol. 10, article id 544
Keywords [en]
fMRI; shifted echo; sampling rate; fast imaging; BOLD; EPI; temporal averaging; data burden
National Category
Psychology (excluding Applied Psychology)
Identifiers
URN: urn:nbn:se:liu:diva-133258DOI: 10.3389/fnins.2016.00544ISI: 000388534300001PubMedID: 27932947OAI: oai:DiVA.org:liu-133258DiVA, id: diva2:1057489
Available from: 2016-12-18 Created: 2016-12-15 Last updated: 2017-11-29

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Witt, SuzanneWarntjes, Marcel Jan BertusEngström, Maria
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Center for Medical Image Science and Visualization (CMIV)Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Clinical Physiology in LinköpingDivision of Radiological Sciences
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Frontiers in Neuroscience
Psychology (excluding Applied Psychology)

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CiteExportLink to record
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