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Probiotics for treatment and primary prevention of allergic diseases and asthma: looking back and moving forward
World University of Network, Sweden; Umeå University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. World University of Network, Sweden.
World University of Network, Sweden; University of Alberta, Canada.
World University of Network, Sweden; University of Western Australia, Australia.
2016 (English)In: EXPERT REVIEW OF CLINICAL IMMUNOLOGY, ISSN 1744-666X, Vol. 12, no 6, 625-639 p.Article, review/survey (Refereed) Published
Abstract [en]

Microbial ecosystems cover the surface of the human body and it is becoming increasingly clear that our modern environment has profound effects on microbial composition and diversity. A dysbiotic gut microbiota has been associated with allergic diseases and asthma in cross-sectional and observational studies. In an attempt to restore this dysbiosis, probiotics have been evaluated in randomized controlled trials. Here, we review treatment and primary prevention studies, recent meta-analyses, and discuss the current understanding of the role of probiotics in this context. Many meta-analyses have shown a moderate benefit of probiotics for eczema prevention, whereas there is less evidence of a benefit for other allergic manifestations. Because of very low quality evidence and heterogeneity between studies, specific advice on the most effective regimens cannot yet be given -not even for eczema prevention. To be able to adopt results into specific recommendations, international expert organizations stress the need for well-designed studies.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2016. Vol. 12, no 6, 625-639 p.
Keyword [en]
Diversity; dysbiosis; eczema; gut microbiome; hygiene hypothesis; primary prevention; probiotic
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:liu:diva-133551DOI: 10.1586/1744666X.2016.1147955ISI: 000388687300005PubMedID: 26821735OAI: oai:DiVA.org:liu-133551DiVA: diva2:1060841
Note

Funding Agencies|Arla Foods AB; Danone Nutricia; Nestle Nutrition; BioGaia AB, Sweden; Nestle Nutrition Institute; ALK Abello

Available from: 2016-12-30 Created: 2016-12-29 Last updated: 2017-01-25

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CiteExportLink to record
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Citation style
  • apa
  • ieee
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Language
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More languages
Output format
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  • asciidoc
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