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A hyperelastic fibre-reinforced continuum model of healing tendons with distributed collagen fibre orientations
University of Oxford, England; University of Teknol Malaysia, Malaysia.
Lund University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
University of Oxford, England.
2016 (English)In: Biomechanics and Modeling in Mechanobiology, ISSN 1617-7959, E-ISSN 1617-7940, Vol. 15, no 6, 1457-1466 p.Article in journal (Refereed) Published
Abstract [en]

The healing process of ruptured tendons is problematic due to scar tissue formation and deteriorated material properties, and in some cases, it may take nearly a year to complete. Mechanical loading has been shown to positively influence tendon healing; however, the mechanisms remain unclear. Computational mechanobiology methods employed extensively to model bone healing have achieved high fidelity. This study aimed to investigate whether an established hyperelastic fibre-reinforced continuum model introduced by Gasser, Ogden and Holzapfel (GOH) can be used to capture the mechanical behaviour of the Achilles tendon under loading during discrete timepoints of the healing process and to assess the models sensitivity to its microstructural parameters. Curve fitting of the GOH model against experimental tensile testing data of rat Achilles tendons at four timepoints during the tendon repair was used and achieved excellent fits (0.9903 amp;lt; R-2 amp;lt; 0.9986). A parametric sensitivity study using a three-level central composite design, which is a fractional factorial design method, showed that the collagen-fibre-related parameters in the GOH model-kappa, k(1) and k(2)-had almost equal influence on the fitting. This study demonstrates that the GOH hyperelastic fibre-reinforced model is capable of describing the mechanical behaviour of healing tendons and that further experiments should focus on establishing the structural and material parameters of collagen fibres in the healing tissue.

Place, publisher, year, edition, pages
SPRINGER HEIDELBERG , 2016. Vol. 15, no 6, 1457-1466 p.
Keyword [en]
Tendon healing; Constitutive model; Fibre-reinforced material; Finite element analysis; Fractional factorial design
National Category
Applied Mechanics
Identifiers
URN: urn:nbn:se:liu:diva-133504DOI: 10.1007/s10237-016-0774-5ISI: 000388811700005PubMedID: 26951049OAI: oai:DiVA.org:liu-133504DiVA: diva2:1060902
Note

Funding Agencies|Oxford Mechanobiology Group; Oxford Solid Mechanics Group; BOTNAR Research Centre, Oxford; Biomedical Engineering Department, Lund University

Available from: 2016-12-30 Created: 2016-12-29 Last updated: 2016-12-30

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CiteExportLink to record
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Citation style
  • apa
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