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Towards single molecule detection with simple printed instruments
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-1815-9699
2016 (English)In: American Advanced Materials Congress, India: VBRI Press , 2016Conference paper, Abstract (Other academic)
Abstract [en]

There is now intense pressure on healthcare systems worldwide that will inevitably lead to radical change. Partic ular excitement surrounds the  concept of  wearable  and internetworked analytical  devices, but current technology generally  falls far short of the sensitivity  and  specificity  required  to  make  further  inroads  into  understanding  complex  biochemistries and  appl ying  this knowledge  to  improving  quality  of  life . Most  devices realised to  date , utilise  derived  information  from  physical  sensors  and cannot begin to resolve  the  complexity that can be  revealed by  molecular sensors. A  notable  exception is the  use  of  biose nsors for  continuous in  vivo monitoring and  control  of  diabetes,  but  progressing  beyond  this  important  innovation  requires  a  step change  in  thinking,  since  most  other  desirable  analytes  offer  greater  challenges  than  glucose  in  terms  of the  degree  of discri mination demanded or the low concentrations present in unprocessed samples . Recent ad vances in single - molecule sens ing enable  molecular  counting,  thus  heralding  an  entirely  new ,  calibration - free quantitative  approach able  to  properly  discriminate the  heter ogeneities  implicit  in  living  systems. Rare  and  unusual  events  can  be  distinguished  from  the  noise  a ssociated  with ensemble  studies  and  i ndividual  inter - and  intra - molecular  events  can  be  studied  in  detail . Combining  this technique with  the simplicity  of  e lectroanalysis  and  recent  advances  in  printed  electronics  allows  us  to  conceive  of  powerful  analytical  tools  that could  be  mass  produced  in  a  variety  of  form  factors , suitable  for  emerging  markets  based  around  next  generation  intelligent systems. Add  to  th is  appropriate  sampling  technology  and  we  may  finally  be  able  to  access  the  multifarious  biomarkers  that could allow us to better maintain health in the face of genetic, nutritional and environmental factors, and to personalise tr eatment of  disease  with  ta ilored  pha r maceuticals  and  bioelectronic  medicine. This  presentation  will  review  our  recent  work  on  single molecule  electrochemistry,  the  design  of  printed  electroanalytical  instruments  and  new  approaches  to  minimally  invasive sampling and will speculate o n possible future developments based on combining these leading edge technologies.

Place, publisher, year, edition, pages
India: VBRI Press , 2016.
Keyword [en]
Single molecule electrochemistry; printed electronics; interstitial fluid extraction, wearable biosensors
National Category
Other Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-133675OAI: oai:DiVA.org:liu-133675DiVA: diva2:1062443
Conference
American Advanced Materials Congress, Miami, Florida, USA, 4-9 December 2016
Available from: 2017-01-05 Created: 2017-01-05 Last updated: 2017-01-20Bibliographically approved

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