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EGFR protein overexpression and gene copy number increases in oral tongue squamous cell carcinoma.
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Karolinska University Hospital, S-17176 Stockholm, Sweden. .
Department of Oncology-Pathology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden. Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 50, Bethesda, MD, USA..
Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 50, Bethesda, MD, USA.
Department of Oncology-Pathology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
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2009 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 45, no 9, 1700-1708 p.Article in journal (Refereed) Published
Abstract [en]

New promising therapeutic agents targeting epidermal growth factor receptor (EGFR) have been developed although clinical information concerning EGFR status in oral tongue squamous cell carcinoma (OTSCC) is limited. We investigated EGFR protein expression and gene copy numbers in 78 pretreatment OTSCC paraffin samples. EGFR protein expression was found in all 78 tumours, of which 72% showed an intense staining. Fifty-four percent of the tumours had high (> or =four gene copies) EGFR gene copy numbers. EGFR gene copy number was significantly associated with EGFR protein expression (P=0.002). Pretreatment EGFR staining intensity tended to be associated with non-pathological complete remission after preoperative radiotherapy for Stage II OTSCC. No correlation was found between EGFR status and survival. EGFR FISH results were significantly (P=0.003) higher in more advanced tumours (Stages II, III and IV) than in the tumours in Stage I. Non-smokers exhibited a significantly higher EGFR gene copy number and protein overexpression in Stages I and II OTSCC than smokers (P=0.001, P=0.009). In conclusion, EGFR was found to be overexpressed in all OTSCCs making this cancer type interesting for exploring new therapeutic agents targeting the EGFR receptor.

Place, publisher, year, edition, pages
Pergamon Press, 2009. Vol. 45, no 9, 1700-1708 p.
Keyword [en]
Mouth neoplasms, In situ hybridisation, Fluorescence, Immunohistochemistry
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-133696DOI: 10.1016/j.ejca.2009.02.027ISI: 000266504100031PubMedID: 19332367Scopus ID: 2-s2.0-65849350702OAI: oai:DiVA.org:liu-133696DiVA: diva2:1062628
Available from: 2017-01-07 Created: 2017-01-07 Last updated: 2017-04-27Bibliographically approved

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CiteExportLink to record
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