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Fluorescence in situ hybridization markers for prediction of cervical lymph node metastases.
Department of Oncology-Pathology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden. Genetics Branch, National Institutes of Health, Bethesda, Maryland.
Genetics Branch, National Institutes of Health, Bethesda, Maryland.
Department of Oncology-Pathology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
Department of Oncology-Pathology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
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2009 (English)In: American Journal of Pathology, ISSN 0002-9440, E-ISSN 1525-2191, Vol. 175, no 6, 2637-2645 p.Article in journal (Refereed) Published
Abstract [en]

The presence of lymph node metastases is associated with poor prognosis in early stage cervical cancer. As of yet, no molecular markers predicting lymph node metastases have been identified. We examined single genetic markers and a composite marker, comprised of three fluorescence in situ hybridization (FISH) probes targeting the genes LAMP3, PROX1, and PRKAA1, in pretreatment cervical biopsies from 16 lymph node positive cases and 15 lymph node negative controls from women with stage IB and IIA cervical cancer. In addition, we determined clonal patterns by including CCND1 to compare the clonal constitution of primary tumors and associated lymph node metastases. The composite FISH marker allowed for classification of patients into those with and without lymph node metastases with a sensitivity and specificity of 75% and 87%, respectively (P = 0.001). The positive predictive value and negative predictive value were 86% and 76%, respectively. Clonal patterns varied among the tumors. In many cases, changes between the primary tumor and lymph node metastases in the most common clones may indicate that certain clones have a growth advantage for establishing metastases in lymph nodes. We conclude that the composite FISH marker may be useful for determining risk for subsequent development of lymph node metastases in patients with cervical cancer.

Place, publisher, year, edition, pages
Elsevier, 2009. Vol. 175, no 6, 2637-2645 p.
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-133698DOI: 10.2353/ajpath.2009.090289ISI: 000272600600038PubMedID: 19893027Scopus ID: 2-s2.0-73549092920OAI: oai:DiVA.org:liu-133698DiVA: diva2:1062630
Available from: 2017-01-07 Created: 2017-01-07 Last updated: 2017-04-27Bibliographically approved

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Åvall Lundqvist, Elisabeth
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CiteExportLink to record
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