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Seroprevalence in Household Raised Pigs Indicate High Exposure to GII Noroviruses in Rural Nicaragua
National Autonomous University of Leon UNAN Leon, Nicaragua.
National Autonomous University of Leon UNAN Leon, Nicaragua.
National Autonomous University of Leon UNAN Leon, Nicaragua.
National Autonomous University of Leon UNAN Leon, Nicaragua.
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2016 (English)In: Zoonoses and Public Health, ISSN 1863-1959, E-ISSN 1863-2378, Vol. 63, no 8, 600-607 p.Article in journal (Refereed) Published
Abstract [en]

Information about porcine norovirus (PoNoV), genetically similar to human NoV (HuNoV), is limited from rural areas where household-raised pigs are heavily exposed to faecal material which could facilitate transmission. Histoblood group antigens (HBGAs) are known susceptibility factors to NoV in humans and in a germfree piglet model but their role in susceptibility in the porcine population remains unknown. This study reports: (i) the seroprevalence and antibody titres to human norovirus (NoV) VLPs in household raised pigs; (ii) the distribution of HBGAs in relation to NoV IgG antibody titres and further characterization by blocking of GII. 4 VLP binding to pig gastric mucins (PGM). The majority of pigs were seropositive to all three VLPs tested (58-70%) with seropositivity and cross-reactivity increasing significantly with age. However, pig sera could not block the binding of NoV GII. 4 VLPs (Dijon) to PGM suggesting no previous infection with this genotype. The majority of the pigs were H-positive (84%), a susceptibility factor for human infections. IgG antibody titres were however higher in H-negative (GMT = 247) as compared with H-positive (GMT = 57) pigs, but after age stratification, this difference in antibody titres was only observed in pigs = 1 month of age. In conclusion, serological data show that the porcine population of Nicaragua is highly exposed to NoV infections, and the association to HBGAs warrants further investigation.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 63, no 8, 600-607 p.
Keyword [en]
IgG; porcine norovirus; Nicaragua; zoonosis; HBGA; pig gastric mucin
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:liu:diva-133750DOI: 10.1111/zph.12269ISI: 000389148700004PubMedID: 27174203OAI: oai:DiVA.org:liu-133750DiVA: diva2:1063116
Note

Funding Agencies|NETROPICA [05-N-2010]; Swedish Research Council [LINK 348-2011-7420, UFORSK 348-2013-6587]

Available from: 2017-01-09 Created: 2017-01-09 Last updated: 2017-01-09

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Nordgren, Johan
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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health Sciences
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