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Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways: Relevance to the Pathogenesis of Alzheimers Disease
Banaras Hindu University, Division of Geriatrics, Department of Medicine, Banaras, India.
ICARE Institute of Medical Sciences and Research — Biochemistry, Haldia, India.
Institute of post Graduate Medical Education and Research, — Biochemistry, Kolkata, India.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
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2016 (English)In: Current Alzheimer Research, ISSN 1567-2050, E-ISSN 1875-5828, Vol. 13, no 11, 1232-1248 p.Article, review/survey (Refereed) Published
Abstract [en]

The metabolic turnover of sphingolipids produces several signaling molecules that profoundly affect the proliferation, differentiation and death of cells. In particular, an enormous body of information is available that defines the varied role of ceramide and sphingosine-1-phosphate in cell death and survival. This review specifically examines the role of ceramide and sphingosine-1-phosphate in triggering neuronal death in Alzheimers disease by analyzing the data from post-mortem studies and experimental research. There is compelling evidence that ceramide plays a key role in the neurodegeneration and amyloidogenesis occurring in the brain in Alzheimers disease. Further, it appears that ceramide and amyloid beta protein orchestrate an attack on mitochondria to set in the pathways of cell death. However, the complexity of metabolic and signaling pathways of sphingolipid derivatives precludes an immediate identification of effective drug targets for the therapy of Alzheimers disease.

Place, publisher, year, edition, pages
BENTHAM SCIENCE PUBL LTD , 2016. Vol. 13, no 11, 1232-1248 p.
Keyword [en]
Sphingomyelin; Ceramide; Sphingosine-1-phosphate; Mitochondria; Amyloid beta protein; Apoptosis; Necroptosis; Alzheimers disease
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-133902DOI: 10.2174/1567205013666160603004239ISI: 000390335400004OAI: oai:DiVA.org:liu-133902DiVA: diva2:1064986
Available from: 2017-01-13 Created: 2017-01-13 Last updated: 2017-01-13

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Sinha, Maitrayee Sardar
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CiteExportLink to record
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