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Diffuse Liver Disease: Measurements of Liver Trace Metal Concentrations and R2* Relaxation Rates
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.ORCID iD: 0000-0003-4630-6550
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping.ORCID iD: 0000-0002-4111-1693
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Medicine and Health Sciences.
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2016 (English)Conference paper (Refereed)
Abstract [en]

Introduction

Over the past decade, several methods for measuring of liver iron content (LIC) non-invasively with MRI have been developed and verified. The most promising methods uses relaxometry, measuring either R2- or R2* relaxation rate in the liver1,2. For instance, several studies have shown that there seems to be a linear relationship between R2* and LIC1. However, few of these studies have measured the liver content of other metals, which could also affect the relaxation rates. The goal of this study was to investigate if any trace metals, other than iron could affect the R2* relaxation rate in liver tissue in a patients with diffuse liver disease.

Subjects and methods

75 patients with suspected diffuse liver disease underwent an MRI examination followed by a liver biopsy the same day. The R2* relaxation rate of the water protons in the liver was measured using an axial 3D multi-slice fat-saturated multi-echo turbo field echo sequence (TE=4.60/9.20/13.80/18.40/23.00ms). Regions of interest (ROI) were drawn and R2* was estimated by fitting the mean signal intensity from the ROIs to a mono-exponential decay model. The biopsies were freeze dried and the concentrations of iron, manganese, copper, cobalt and gadolinium were measured using Inductively Coupled Plasma Sector Field Mass Spectrometry (ICP-SFMS). A multiple linear regression analysis was applied to determine which of the measured metals significantly affected the relaxation rate.

Results

A linear regression with the LIC and R2* showed a reasonable fit (Figure 1). The multiple linear regression analysis (Table 1) showed that iron as well as manganese had a significant affect on R2*. Unlike iron however, the regression coefficient of manganese was negative, meaning that an increasing manganese concentration gave a shorter R2* relaxation rate. The same trend can be seen when plotting the manganese concentration against R2* (Figure 2).

Place, publisher, year, edition, pages
2016.
National Category
Medical and Health Sciences Radiology, Nuclear Medicine and Medical Imaging Medical Laboratory and Measurements Technologies Water Engineering Pharmaceutical Sciences Metallurgy and Metallic Materials
Identifiers
URN: urn:nbn:se:liu:diva-134175OAI: oai:DiVA.org:liu-134175DiVA: diva2:1069183
Conference
ESMRMB 29 Sep - 1 Oct 2016, Vienna Austria
Available from: 2017-01-27 Created: 2017-01-27 Last updated: 2017-02-02Bibliographically approved

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Karlsson, MarkusForsgren, MikaelDahlström, NilsLeinhard Dahlqvist, OlofNorén, BengtEkstedt, MattiasKechagias, StergiosLundberg, Peter
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Division of Radiological SciencesCenter for Medical Image Science and Visualization (CMIV)Faculty of Medicine and Health SciencesDepartment of Radiation PhysicsDepartment of Radiology in LinköpingDivision of Cardiovascular MedicineDepartment of Gastroentorology
Medical and Health SciencesRadiology, Nuclear Medicine and Medical ImagingMedical Laboratory and Measurements TechnologiesWater EngineeringPharmaceutical SciencesMetallurgy and Metallic Materials

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