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Erythrocyte fatty acid composition does not influence levels of free, bioavailable, and total 25-hydroxy vitamin D
County Hospital Kalmar, Sweden; Linnaeus University, Sweden.
County Hospital Kalmar, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. County Hospital Kalmar, Sweden.
County Hospital Kalmar, Sweden.
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2017 (English)In: SCANDINAVIAN JOURNAL OF CLINICAL and LABORATORY INVESTIGATION, ISSN 0036-5513, Vol. 77, no 1, 45-52 p.Article in journal (Refereed) Published
Abstract [en]

In vitro, mono- and polyunsaturated fatty acids (FAs) may decrease the binding affinity of vitamin D metabolites for vitamin D-binding protein, which in turn may influence their bioavailability. FAs incorporated as phospholipids in erythrocyte (ery-) cell membranes reflect dietary intake. The purpose of this study was to investigate ery-FA composition in relation to markers for vitamin D. In healthy females (age 22.6 +/- 2.0 years) total 25(OH)D was measured by LC-MS/MS (n=78), free 25(OH)D with ELISA (n=64 of 78), and bioavailable 25(OH)D was calculated. Analysis of ery-FA composition was by gas chromatography (n=56 of 78). A strong correlation between total 25(OH)D and free 25(OH)D was seen (r=.66, pamp;lt;.001), and between total-25(OH)D and bioavailable 25(OH)D (r=.68, pamp;lt;.001). No correlations between 25(OH)D fractions and specific fatty acids were found, and in particular, no associations with mono- and poly-unsaturated FA compositions. All 25(OH)D fractions were correlated with leptin (total 25(OH)D (r=-.33, pamp;lt;.003); bioavailable 25(OH)D (r=-.47, pamp;lt;.001); free 25(OH)D (r=-.44, pamp;lt;.001). Associations were found between PTH and total 25(OH)D (r=-.35, p=.002) and weaker between bioavailable 25(OH)D (r=-.35, p=.040) and free 25(OH)D (r=-.28, p=.079). All fractions of 25(OH)D appear to correlate in a similar way to PTH, BMI and body fat (leptin). No association was found between ery-FA composition and free/bioavailable 25(OH)D. It is unlikely that FAs are a strong uncoupling factor of DBP-bound 25(OH)D.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2017. Vol. 77, no 1, 45-52 p.
Keyword [en]
Erythrocyte membrane; fatty acids; leptin; lipids; parathyroid hormone; Vitamin D
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:liu:diva-134210DOI: 10.1080/00365513.2016.1258724ISI: 000390847200009PubMedID: 27905210OAI: oai:DiVA.org:liu-134210DiVA: diva2:1069829
Note

Funding Agencies|Medical Council of Southeast Sweden (FORSS)

Available from: 2017-01-30 Created: 2017-01-29 Last updated: 2017-01-30

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CiteExportLink to record
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Citation style
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