Optical guidance for stereotactic brain tumor biopsy procedures-preliminary clinical evaluation
2017 (English)Conference paper, Abstract (Refereed)
During stereotactic biopsy on suspected tumors in the brain, tissue samples are harvested to determine the malignancy. To provide guidance for finding the diagnostic tumor sites and to avoid vessel rupture, an application specific probe was developed. The setup incorporated spectroscopy for detection of 5-aminolevulinic acid induced protoporphyrin (PpIX) fluorescence and blood flow using laser Doppler flowmetry. The PpIX fluorescence was significantly different in the tumor compared to the gliotic marginal zone (p < 0.05). In conclusion, the systems made real-time tumor detection and vessel tracking possible. Moreover, the autofluorescence and blood perfusion could be studied in the tumor.
Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2017.
Clinical and Translational Neurophotonics
Other Medical Engineering
IdentifiersURN: urn:nbn:se:liu:diva-134373OAI: oai:DiVA.org:liu-134373DiVA: diva2:1072536
Photonics West 28 January - 2 February 2017
FunderLinköpings universitetSwedish Childhood Cancer FoundationWenner-Gren FoundationsMedical Research Council of Southeast Sweden (FORSS)