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Reversal learning strategy in adolescence is associated with prefrontal cortex activation
Linköping University, Center for Social and Affective Neuroscience (CSAN). Linköping University, Faculty of Medicine and Health Sciences. Charite, Germany.
Charite, Germany; Max Planck Institute Human Dev, Germany.
Charite, Germany; NeuroCure Excellence Cluster, Germany.
Charite, Germany.
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2017 (English)In: European Journal of Neuroscience, ISSN 0953-816X, E-ISSN 1460-9568, Vol. 45, no 1, 129-137 p.Article in journal (Refereed) Published
Abstract [en]

Adolescence is a critical maturation period for human cognitive control and executive function. In this study, a large sample of adolescents (n=85) performed a reversal learning task during functional magnetic resonance imaging. We analyzed behavioral data using a reinforcement learning model to provide individually fitted parameters and imaging data with regard to reward prediction errors (PE). Following a model-based approach, we formed two groups depending on whether individuals tended to update expectations predominantly for the chosen stimulus or also for the unchosen one. These groups significantly differed in their problem behavior score obtained using the child behavior checklist (CBCL) and in a measure of their developmental stage. Imaging results showed that dorsolateral striatal areas covaried with PE. Participants who relied less on learning based on task structure showed less prefrontal activation compared with participants who relied more on task structure. An exploratory analysis revealed that PE-related activity was associated with pubertal development in prefrontal areas, insula and anterior cingulate. These findings support the hypothesis that the prefrontal cortex is implicated in mediating flexible goal-directed behavioral control.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2017. Vol. 45, no 1, 129-137 p.
Keyword [en]
adolescents; prediction error; prefrontal cortex; reversal learning
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-134607DOI: 10.1111/ejn.13401ISI: 000392487100012PubMedID: 27628616OAI: oai:DiVA.org:liu-134607DiVA: diva2:1075992
Note

Funding Agencies|Volkswagen Foundation [II/84 452]; Bundesministerium fur Bildung und Forschung (BMBF) [01ZX1311E]; Deutsche Forschungsgemeinschaft [GRK-1123, HE 2597/13-1]

Available from: 2017-02-21 Created: 2017-02-21 Last updated: 2017-03-02Bibliographically approved

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Böhme, RebeccaWold, Andrew
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Center for Social and Affective Neuroscience (CSAN)Faculty of Medicine and Health SciencesDepartment of Clinical and Experimental Medicine
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CiteExportLink to record
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Cite
Citation style
  • apa
  • harvard1
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  • modern-language-association-8th-edition
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More styles
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