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Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology. State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an, China.
Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
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2017 (English)In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 8, no 36, p. 60015-60024Article in journal (Refereed) Published
Abstract [en]

Emerging evidence has implicated a pivotal role for lysyl oxidase (LOX) in cancer progression and metastasis. Whilst the majority of work has focused on the extracellular matrix cross-linking role of LOX, the exact function of intracellular LOX localisation remains unclear. In this study, we analysed the LOX expression patterns in the nuclei of rectal cancer patient samples and determined the clinical significance of this expression. Nuclear LOX expression was significantly increased in patient lymph node metastases compared to their primary tumours. High nuclear LOX expression in tumours was correlated with a high rate of distant metastasis and increased recurrence. Multivariable analysis showed that high nuclear LOX expression was also correlated with poor overall survival and disease free survival. Furthermore, we are the first to identify LOX enzyme isoforms (50 kDa and 32 kDa) within the nucleus of colon cancer cell lines by confocal microscopy and Western blot. Our results show a powerful link between nuclear LOX expression in tumours and patient survival, and offer a promising prognostic biomarker for rectal cancer patients.

Place, publisher, year, edition, pages
Impact journals , 2017. Vol. 8, no 36, p. 60015-60024
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Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-134762DOI: 10.18632/oncotarget.9623ISI: 000408944300001PubMedID: 27231855OAI: oai:DiVA.org:liu-134762DiVA, id: diva2:1076898
Note

Funding agencies: Swedish Cancer Foundation; Research Council of South East Sweden; Liu Cancer

Available from: 2017-02-24 Created: 2017-02-24 Last updated: 2018-05-03

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Adell, GunnarHolmlund, BirgittaSun, Xiao-Feng

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Division of Clinical SciencesFaculty of Medicine and Health SciencesDepartment of OncologyDivision of Surgery, Orthopedics and OncologyDivision of Cell Biology
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