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Cortisol levels in hair are altered in irritable bowel syndrome - A case control study in primary care.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Gastroentorology.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry.
National board of forensic medicine, Sweden.
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2017 (English)In: Journal of Psychosomatic Research, ISSN 0022-3999, E-ISSN 1879-1360, Vol. 93, 69-75 p., S0022-3999(16)30613-4Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Stress is an important component in the pathophysiology of irritable bowel syndrome (IBS). Long term Hypothalamus Pituitary Adrenal (HPA)-axis activity can be studied by measuring hair cortisol concentrations (HCC). Some previous studies have indicated a dysregulated HPA-axis in IBS patients, but cortisol levels in hair have not yet been studied. We investigated whether HCC and self-reported stress differentiate IBS patients from controls.

METHODS: In a cross-sectional study within 10 Swedish Primary Health Care Centers we compared patients in working age with active IBS to patients without GI complaints. The participants donated hair samples and completed questionnaires including a scale of self-reported perceived stress (PSS). 169 Rome III-fulfilling IBS patients and 316 non-IBS patients were available for final analyses.

RESULTS: IBS patients had significantly lower HCC, median=16.3pg/mg, IQR=26.9pg/mg, compared to non-IBS patients, median=22.8pg/mg, IQR=29.1pg/mg. There was also a difference in the distribution of HCC quintiles between the two groups, with 30.2% IBS patients and 14.2% of non-IBS patients in the lowest quintile of HCC. PSS was higher among IBS patients with a mean (SD) total score of 25.3 (8.0) compared to controls 21.4, (7.5). Quintiles of HCC and PSS stayed significantly but very weakly related to IBS (B=-0.332, Std error=0.146, p<0.005) in multivariable analyses.

CONCLUSION: This study suggests a possible suppression of the HPA-axis activity in a considerable portion of IBS patients.

Place, publisher, year, edition, pages
2017. Vol. 93, 69-75 p., S0022-3999(16)30613-4
Keyword [en]
Cortisol in hair, HPA-axis, Irritable bowel syndrome, Primary care, Stress
National Category
Family Medicine
Identifiers
URN: urn:nbn:se:liu:diva-134923DOI: 10.1016/j.jpsychores.2016.12.009ISI: 000393270900011PubMedID: 28107896OAI: oai:DiVA.org:liu-134923DiVA: diva2:1078100
Note

Funding agencies: research council of Southeast Sweden (FORSS)

Available from: 2017-03-02 Created: 2017-03-02 Last updated: 2017-03-14

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Norlin, Anna-KarinWalter, SusannaTheodorsson, ElvarGrodzinsky, EwaFaresjö, Åshild
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Division of Community MedicineFaculty of Medicine and Health SciencesDivision of Neuro and Inflammation ScienceDepartment of GastroentorologyDivision of Microbiology and Molecular MedicineDepartment of Clinical ChemistryDepartment of Social and Welfare StudiesDivision of Drug ResearchResearch & Development Unit in Local Health Care
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CiteExportLink to record
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