liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
New hypothesis on pontine-frontal eye field connectivity in Kleine-Levin syndrome
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-2167-2450
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Neurology. Linköping University, Center for Medical Image Science and Visualization (CMIV). Uppsala University, Sweden.
Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).
2016 (English)In: Journal of Sleep Research, ISSN 0962-1105, E-ISSN 1365-2869, Vol. 25, no 6, 716-719 p.Article in journal (Refereed) Published
Abstract [en]

Previous studies have indicated involvement of the thalamus and the pons in Kleine-Levin syndrome. In the present study, functional connectivity of the thalamus and the pons was investigated in asymptomatic patients with Kleine-Levin syndrome and healthy controls. Twelve patients and 14 healthy controls were investigated by functional magnetic resonance imaging during rest. Resting state images were analysed using seed regions of interest in the thalamus and the pons. The results showed significantly lower functional connectivity between the pons and the frontal eye field in persons with Kleine-Levin syndrome compared with healthy controls. There were no connectivity differences involving the thalamus. Based on these findings, a relation is proposed between the sleep disorder Kleine-Levin syndrome and cerebral control of eye movements, which in turn is related to visual attention and working memory. This hypothesis has to be tested in future studies of oculomotor control in Kleine-Levin syndrome.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 25, no 6, 716-719 p.
Keyword [en]
periodic idiopathic hypersomnia; saccades; nystagmus; working memory
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-134994DOI: 10.1111/jsr.12428ISI: 000393032300012PubMedID: 27230978OAI: oai:DiVA.org:liu-134994DiVA: diva2:1078790
Note

Funding Agencies|KLS Foundation; Linkoping University; Linkoping University Hospital

Available from: 2017-03-06 Created: 2017-03-06 Last updated: 2017-03-26

Open Access in DiVA

fulltext(230 kB)2 downloads
File information
File name FULLTEXT01.pdfFile size 230 kBChecksum SHA-512
28922cbf6428a3821dfb46b0263947a658023fb30436ad360f405d197f40b964b6d6183f496dfe53f24d8bf69ecb070432c5dcfda7799f6c70cd2ca9621121f2
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Engström, MariaLandtblom, Anne-MarieKarlsson, Thomas
By organisation
Division of Radiological SciencesFaculty of Medicine and Health SciencesCenter for Medical Image Science and Visualization (CMIV)Division of Neuro and Inflammation ScienceDepartment of NeurologyDisability ResearchFaculty of Arts and Sciences
In the same journal
Journal of Sleep Research
Neurology

Search outside of DiVA

GoogleGoogle Scholar
Total: 2 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 43 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf