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Optical tumor and blood vessel detection to enhance accuracy and safety of stereotactic brain tumor biopsies
Ludwig Maximilians university in Munich.
MRC Systems GmbH, Heidelberg, Germany.
Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping university. (MINT)
Laser-Forschungslabor, LIFE-Zentrum, Klinikum der Universität München, Munich, Germany .
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2017 (English)Conference paper, (Refereed)
Abstract [en]

Safety and accuracy of stereotactic brain tumor biopsies can be improved by integrating a fiber-optical probe into the biopsy needle. After administering 5-aminolevulinic acid, the fluorophore protoporphyrin IX (PpIX) is accumulated in vital tumor tissue, which may then be localized via fluorescence detection. Apparently, blood covered tumor tissue only produces a non-vanishing signal when excited with red light around 633 nm. By illuminating the tissue that is to be sampled and comparing the remitted intensities at two wavelengths with strongly differing hemoglobin absorption, blood vessels can be recognized up to 800-1200 µm ahead of the probe to avoid intracerebral hemorrhage.

Place, publisher, year, edition, pages
San Francisco, 2017.
Series
Clinical and Translational Neurophotonics
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-134850OAI: oai:DiVA.org:liu-134850DiVA: diva2:1079585
Conference
Photonics West
Available from: 2017-03-08 Created: 2017-03-08 Last updated: 2017-03-21Bibliographically approved

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Haj-Hosseini, Neda
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