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Inverse relationship between erythrocyte size and platelet reactivity in elderly.
Department of Internal Medicine, Vrinnevi Hospital, Norrköping, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in East Östergötland.
NVS, Neurogeriatrics, Karolinska Institutet, Huddinge, Karolinska University Hospital, Geriatrics, Huddinge.
NVS, Neurogeriatrics, Karolinska Institutet, Huddinge, Karolinska University Hospital, Geriatrics, Huddinge.
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2016 (English)In: Platelets, ISSN 0953-7104, E-ISSN 1369-1635, 1-5 p.Article in journal (Refereed) Published
Abstract [en]

Previous work indicates that erythrocytes (RBCs) accumulate β-amyloid X-40 (Aβ40) in individuals with Alzheimer disease (AD) and to a lesser extent in healthy elderly. The toxin damages RBCs and increases their mean corpuscular volume (MCV). Furthermore, AD platelets demonstrate lower reactivity. This study investigated interactions between RBCs and platelets. Older individuals with moderate hypertension (n = 57) were classified into two groups, depending on MCV in whole blood: The MCV(high) group comprised individuals with higher MCV (n = 27; 97 ± 3(SD) fl) and MCV(low) group had relatively lower MCV (n = 30; 90 ± 3(SD) fl). Flow cytometry was used to determine platelet reactivity, i.e., the surface binding of fibrinogen after provocation. Adenosine diphosphate (ADP) and a thrombin receptor-activating protein (TRAP-6) were used as agonists. Subsequently, blood cells were divided according to density into 17 subfractions. Intra-RBC Aβ40 content was analyzed and in all platelet populations surface-bound fibrinogen was determined to estimate platelet in vivo activity. We found Aβ40 inside RBCs of approximately 50% of participants, but the toxin did not affect MCV and platelet reactivity. In contrast, MCV associated inversely with platelet reactivity as judged from surface-attached fibrinogen after ADP (1.7 μmol/L) (p < 0.05) and TRAP-6 provocation (57 μmol/L (p = 0.01) and 74 μmol/L (p < 0.05)). In several density fractions (nos. 3, 4, 8, 11-13 (p < 0.05) and nos. 5-7 (p < 0.01)) MCV linked inversely with platelet-attached fibrinogen. In our community-dwelling sample, enhanced MCV associated with decreased platelet reactivity and lower in vivo platelet activity. It resembles RBCs and platelet behavior in AD-type dementia.

Place, publisher, year, edition, pages
2016. 1-5 p.
Keyword [en]
Alzheimer´s disease, elderly, erythrocytes, fibrinogen, mean corpuscular volume, platelet activity, platelet density, platelet reactivity, β-amyloid
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:liu:diva-135130DOI: 10.1080/09537104.2016.1206196PubMedID: 27557548OAI: oai:DiVA.org:liu-135130DiVA: diva2:1079889
Available from: 2017-03-09 Created: 2017-03-09 Last updated: 2017-03-21Bibliographically approved

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Nilsson, Staffan
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Division of Community MedicineFaculty of Medicine and Health SciencesLocal Health Care Services in East Östergötland
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