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Successful autologous haematopoietic stem cell transplantation for refractory myasthenia gravis - a case report
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Social and Welfare Studies. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Haematology.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Neurology.
University of Uppsala Hospital, Sweden.
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2017 (English)In: Neuromuscular Disorders, ISSN 0960-8966, E-ISSN 1873-2364, Vol. 27, no 1, 90-93 p.Article in journal (Refereed) Published
Abstract [en]

Myasthenia gravis (MG) is an autoimmune disease, with immune reactivity against the post-synaptic endplate of the neuromuscular junction. Apart from symptomatic treatment with choline esterase blockers, many patients also require immunomodulatory treatment. Despite existing treatment options, some patients are treatment refractory. We describe a patient with severe MG refractory to corticosteroids, four oral immunosuppressants, cyclophosphamide, rituximab and bortezomib who was treated with autologous haematopoietic stem cell transplantation. Two years after this, the patient has significantly improved in objective tests and in quality of life and leads an active life. Diplopia is her only remaining symptom and she is completely free of medication for MG. We believe that autologous haematopoietic stem cell transplantation can be an effective therapeutic option for carefully selected cases of severe, treatment refractory MG. (c) 2016 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2017. Vol. 27, no 1, 90-93 p.
Keyword [en]
Myasthenia gravis; Autologous haematopoietic stem cell transplantation
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-135402DOI: 10.1016/j.nmd.2016.09.020ISI: 000393247400014PubMedID: 27863874OAI: oai:DiVA.org:liu-135402DiVA: diva2:1081490
Available from: 2017-03-14 Created: 2017-03-14 Last updated: 2017-03-14

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Håkansson, IreneSandstedt, AnnaLundin, Fredrik
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Social and Welfare StudiesDepartment of HaematologyDepartment of Neurology
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Neuromuscular Disorders
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CiteExportLink to record
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