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High target attainment for β-lactam antibiotics in intensive care unit patients when actual minimum inhibitory concentrations are applied.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Infectious Diseases.
Department of Anaesthesia and Intensive Care, Kalmar County Hospital, Kalmar, Sweden.
Department of Anaesthesia and Intensive Care , Central Hospital , Växjö Sweden.
Department of Infectious Diseases, Central Hospital, Växjö, Sweden.
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2017 (English)In: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 36, no 3, 11 p.553-563 p.Article in journal (Refereed) Published
Abstract [en]

Patients in the intensive care unit (ICU) are at risk for suboptimal levels of β-lactam antibiotics, possibly leading to poor efficacy. Our aim was to investigate whether the actual minimum inhibitory concentration (MIC) compared to the more commonly used arbitrary epidemiological cut-off values (ECOFFs) would affect target attainment in ICU patients on empirical treatment with broad-spectrum β-lactam antibiotics and to identify risk factors for not reaching target. In a prospective, multicenter study, ICU patients ≥18 years old and treated with piperacillin/tazobactam, meropenem, or cefotaxime were included. Clinical and laboratory data were recorded. Serum trough antibiotic levels from three consecutive days were analyzed by liquid chromatography-mass spectrometry (LC-MS). The target was defined as the free trough concentration above the MIC (100% fT). MIC was used as the target and, when available, the actual MIC (MIC) was applied. The median age of the patients was 70 years old, 52% (58/111) were males, and the median estimated glomerular filtration rate (eGFR) was 48.0 mL/min/1.73 m. The rate of patients reaching 100% fT greater than MIC was higher (89%, 31/35) compared to the same patients using MIC (60%, p = 0.002). In total, 55% (61/111) reached 100% fT greater than MIC. Increased renal clearance was independently associated to not reaching 100% fT greater than MIC. On repeated sampling, greater than77% of patients had stable serum drug levels around the MIC. Serum concentrations of β-lactam antibiotics vary extensively between ICU patients. The rate of patients not reaching target was markedly lower for the actual MIC than when the arbitrary MIC based on the ECOFF was used, which is important to consider in future studies. [ABSTRACT FROM AUTHOR]

Place, publisher, year, edition, pages
Springer, 2017. Vol. 36, no 3, 11 p.553-563 p.
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-135475DOI: 10.1007/s10096-016-2832-4PubMedID: 27815778OAI: oai:DiVA.org:liu-135475DiVA: diva2:1081954
Available from: 2017-03-15 Created: 2017-03-15 Last updated: 2017-03-16

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Hällgren, AnitaOscarsson, AnnaCarlsson, Björn
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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health SciencesDepartment of Infectious DiseasesDivision of Drug ResearchDepartment of Anaesthesiology and Intensive Care in LinköpingDepartment of Clinical Pharmacology
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European Journal of Clinical Microbiology and Infectious Diseases
Infectious Medicine

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