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Cognitive and neural consequences of memory suppression in major depressive disorder
Stanford University, USA; VA Boston Healthcare Syst, MA 02130 USA.
VA Boston Healthcare Syst, MA 02130 USA; University of San Francisco, CA 94117 USA.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Social and Affective Neuroscience (CSAN). VA Boston Healthcare Syst, MA 02130 USA.
VA Boston Healthcare Syst, MA 02130 USA; Boston University, MA 02118 USA.
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2017 (English)In: Cognitive, Affective, & Behavioral Neuroscience, ISSN 1530-7026, E-ISSN 1531-135X, Vol. 17, no 1, 77-93 p.Article in journal (Refereed) Published
Abstract [en]

Negative biases in cognition have been documented consistently in major depressive disorder (MDD), including difficulties in the ability to control the processing of negative material. Although negative information-processing biases have been studied using both behavioral and neuroimaging paradigms, relatively little research has been conducted examining the difficulties of depressed persons with inhibiting the retrieval of negative information from long-term memory. In this study, we used the think/no-think paradigm and functional magnetic resonance imaging to assess the cognitive and neural consequences of memory suppression in individuals diagnosed with depression and in healthy controls. The participants showed typical behavioral forgetting effects, but contrary to our hypotheses, there were no differences between the depressed and nondepressed participants or between neutral and negative memories. Relative to controls, depressed individuals exhibited greater activity in right middle frontal gyrus during memory suppression, regardless of the valence of the suppressed stimuli, and differential activity in the amygdala and hippocampus during memory suppression involving negatively valenced stimuli. These findings indicate that depressed individuals are characterized by neural anomalies during the suppression of long-term memories, increasing our understanding of the brain bases of negative cognitive biases in MDD.

Place, publisher, year, edition, pages
SPRINGER , 2017. Vol. 17, no 1, 77-93 p.
Keyword [en]
Major depressive disorder (MDD); Functional magnetic resonance imaging (fMRI); Memory suppression; Think/No-Think (TNT); Cognitive neuroscience; Negative valence
National Category
Psychology (excluding Applied Psychology)
Identifiers
URN: urn:nbn:se:liu:diva-135721DOI: 10.3758/s13415-016-0464-xISI: 000393772800004PubMedID: 27649971OAI: oai:DiVA.org:liu-135721DiVA: diva2:1082759
Note

Funding Agencies|NSF [0801700, DGE-1147470]; NIMH [T32 MH020016, R01-MH59259]; UK Medical Research Council [MC-A060-5PR00]

Available from: 2017-03-17 Created: 2017-03-17 Last updated: 2017-03-17

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Hamilton, Paul
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Citation style
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