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Emerging cardiac non-coding landscape: The importance of meta-analysis
Madurai Kamaraj University, India; Bar Ilan University, Israel.
Madurai Kamaraj University, India.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Madurai Kamaraj University, India.
2017 (English)In: Biochimie, ISSN 0300-9084, E-ISSN 1638-6183, Vol. 133, 87-94 p.Article, review/survey (Refereed) Published
Abstract [en]

The invention of transcriptome-wide deep sequencing technology has fundamentally changed our understanding of the complex networks that mediate cardiac functions. Since its inception, researchers have uncovered various novel pathways and transcripts that could be one day used for therapeutics and diagnostics. The characterization of various non-protein coding RNAs (ncRNAs) has aided the study of cardiac manifestation in more detail. Although numerous studies have unearthed the importance of miRNA and IncRNA, the existence and importance of other ncRNAs have been neglected due to their unusual behaviors and outdated ideologies. Recent studies focused on these neglected molecules have proven that these molecules are functional and of great potential. This review brings into focus some of those ncRNAs that were once thought to be futile and not expressed in the heart with an emphasis on the use of meta-data. (C) 2016 Elsevier B.V.and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER , 2017. Vol. 133, 87-94 p.
Keyword [en]
Non-coding RNA; Cardiology; piRNA; snoRNA; Meta-analysis
National Category
Bioinformatics and Systems Biology
Identifiers
URN: urn:nbn:se:liu:diva-135720DOI: 10.1016/j.biochi.2016.12.018ISI: 000393627100011PubMedID: 28038934OAI: oai:DiVA.org:liu-135720DiVA: diva2:1082766
Note

Funding Agencies|DBT [BT/PR 15077/GBD/27/300/2011, BT/PR/10547/AAQ/3/673/2014]; SERB Govt. of India [SR/FT/LS-48/2011, EMR/2014/000892]; "The Mina and Everard Goodman Faculty of Life Sciences Masters Degree Fellowship", Bar-Ilan University, Israel

Available from: 2017-03-17 Created: 2017-03-17 Last updated: 2017-11-29

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