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Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Department of Oncology-Pathology, Karolinska Institute, SE-171 76 Stockholm, Sweden.
Department of Molecular Biology and Genetics, Gebze Technical University, 41400, Gebze, Kocaeli, Turkey.
Department of Immunology, Genetics and Pathology, Section of Oncology, Uppsala University, Uppsala, Sweden.
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2016 (English)In: Trends in Cancer, ISSN 2405-8033, Vol. 2, no 11, 7 p.657-663 p.Article, review/survey (Refereed) Published
Abstract [en]

Solid tumors contain slowly proliferating cells that show limited sensitivity to conventional cell cycle-active chemotherapeutic drugs. Tumor cells that are not exposed to therapeutically relevant drug concentrations and/or are insensitive to drugs survive treatment and repopulate tumors between treatment cycles. Cancer cells residing in hypoxic and nutritionally compromised environments are expected to have limited metabolic plasticity and to be susceptible to the manipulation of energy supply pathways. Drug screening campaigns using glucose-depleted tumor cells and 3D tumor cell cultures have resulted in the identification of inhibitors of mitochondrial energy production.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 2, no 11, 7 p.657-663 p.
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:liu:diva-136133DOI: 10.1016/j.trecan.2016.10.009OAI: oai:DiVA.org:liu-136133DiVA: diva2:1085310
Available from: 2017-03-28 Created: 2017-03-28 Last updated: 2017-05-04Bibliographically approved

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