Eradicating Quiescent Tumor Cells by Targeting Mitochondrial BioenergeticsShow others and affiliations
2016 (English)In: Trends in cancer, ISSN 2405-8025, E-ISSN 2405-8033, Vol. 2, no 11, p. 7p. 657-663Article, review/survey (Refereed) Published
Abstract [en]
Solid tumors contain slowly proliferating cells that show limited sensitivity to conventional cell cycle-active chemotherapeutic drugs. Tumor cells that are not exposed to therapeutically relevant drug concentrations and/or are insensitive to drugs survive treatment and repopulate tumors between treatment cycles. Cancer cells residing in hypoxic and nutritionally compromised environments are expected to have limited metabolic plasticity and to be susceptible to the manipulation of energy supply pathways. Drug screening campaigns using glucose-depleted tumor cells and 3D tumor cell cultures have resulted in the identification of inhibitors of mitochondrial energy production.
Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 2, no 11, p. 7p. 657-663
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:liu:diva-136133DOI: 10.1016/j.trecan.2016.10.009ISI: 000432227400005PubMedID: 28741504OAI: oai:DiVA.org:liu-136133DiVA, id: diva2:1085310
2017-03-282017-03-282021-04-21Bibliographically approved