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Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 4. Speech outcomes in 5-year-olds - velopharyngeal competency and hypernasality
Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
University of Gothenburg, Sweden.
University of Copenhagen, Denmark.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
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2017 (English)In: Journal of Plastic Surgery and Hand Surgery, ISSN 2000-656X, E-ISSN 2000-6764, Vol. 51, no 1, 27-37 p.Article in journal (Refereed) Published
Abstract [en]

Background and aim: Adequate velopharyngeal function and speech are main goals in the treatment of cleft palate. The objective was to investigate if there were differences in velopharyngeal competency (VPC) and hypernasality at age 5 years in children with unilateral cleft lip and palate (UCLP) operated on with different surgical methods for primary palatal repair. A secondary aim was to estimate burden of care in terms of received additional secondary surgeries and speech therapy. Design: Three parallel group, randomised clinical trials were undertaken as an international multicentre study by 10 cleft teams in five countries: Denmark, Finland, Sweden, Norway, and the UK. Methods: Three different surgical protocols for primary palatal repair were tested against a common procedure in the total cohort of 448 children born with a non-syndromic UCLP. Speech audio and video recordings of 391 children (136 girls, 255 boys) were available and perceptually analysed. The main outcome measures were VPC and hypernasality from blinded assessments. Results: There were no statistically significant differences between the prevalences in the arms in any of the trials. VPC: Trial 1, A: 58%, B: 61%; Trial 2, A: 57%, C: 54%; Trial 3, A: 35%, D: 51%. No hypernasality: Trial 1, A: 54%, B: 44%; Trial 2, A: 47%, C: 51%; Trial 3, A: 34%, D: 49%. Conclusions: No differences were found regarding VPC and hypernasality at age 5 years after different methods for primary palatal repair. The burden of care in terms of secondary pharyngeal surgeries, number of fistulae, and speech therapy visits differed.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2017. Vol. 51, no 1, 27-37 p.
Keyword [en]
Randomised clinical trial; Scandcleft; primary palatal repair; unilateral cleft lip and palate; speech; intercentre study; cross-linguistic
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-136209DOI: 10.1080/2000656X.2016.1254645ISI: 000395170100005PubMedID: 28218551OAI: oai:DiVA.org:liu-136209DiVA: diva2:1086269
Note

Funding Agencies|Swedish Research Council for Health, Working Life and Welfare [2011-1443]

Available from: 2017-03-31 Created: 2017-03-31 Last updated: 2017-04-03

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Lundeborg, Inger
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health Sciences
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