INFLUENCE OF THE SEPARATION PARAMETERS APPLIED FOR DETERMINATION OF IMPURITIES FDG AND CLDG
2017 (English)In: Farmacia, ISSN 0014-8237, E-ISSN 2065-0019, Vol. 65, no 1, 153-158 p.Article in journal (Refereed) Published
2-fluoro-2-deoxy-D-glucose (FDG) and 2-chloro-2-deoxy-D-glucose (CIDG) are chemical impurities found in the 2-[F-18]fluoro-2-deoxy-D-glucose products (F-18-FDG). The objective of this study was to find the best condition for the separation of FDG and CIDG, evaluating different columns under various operating conditions. Chromatographic parameters such as column temperature, composition and flow rate of the mobile phase were the independent variables used in the optimization process. The optimized method was validated and validation results showed a good accuracy, repeatability and reproducibility.
Place, publisher, year, edition, pages
SOC STINTE FARMACEUTICE ROMANIA , 2017. Vol. 65, no 1, 153-158 p.
Chemical impurities; radio-HPAEC; validation
Chemical Process Engineering
IdentifiersURN: urn:nbn:se:liu:diva-136189ISI: 000394478400024OAI: oai:DiVA.org:liu-136189DiVA: diva2:1086618
Funding Agencies|Sectorial Operational Programme Human Resources Development (SOP HRD) from the European Social Fund; Romanian Government [POSDRU/159/1.5/S/137390/]2017-04-032017-04-032017-04-03