liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Prednisolone is associated with a worse lipid profile than hydrocortisone in patients with adrenal insufficiency
Endocrinol Charlottenburg, Germany.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Endocrinology.
Shire Int GmbH, Switzerland.
Shire, MA USA.
Show others and affiliations
2017 (English)In: Endocrine Connections, ISSN 2049-3614, E-ISSN 2049-3614, Vol. 6, no 1Article in journal (Refereed) Published
Abstract [en]

Objective: Prednisolone is used as glucocorticoid replacement therapy for adrenal insufficiency (AI). Recent data indicate that its use in AI is associated with low bone mineral density. Data on risk factors for cardiovascular disease in patients with AI treated with prednisolone are scarce, despite this condition being the predominant cause of excess mortality. We aimed to address this question using real-world data from the European Adrenal Insufficiency Registry (EU-AIR). Design/methods: EU-AIR, comprising of 19 centres across Germany, the Netherlands, Sweden and the UK, commenced enrolling patients with AI in August 2012. Patients receiving prednisolone (3-6 mg/day, n = 50) or hydrocortisone (15-30 mg/day, n = 909) were identified and grouped at a ratio of 1: 3 (prednisolone: hydrocortisone) by matching for gender, age, duration and type of disease. Data from baseline and follow-up visits were analysed. Data from patients with congenital adrenal hyperplasia were excluded. Results: Significantly higher mean +/- s. d. total (6.3 +/- 1.6 vs 5.4 +/- 1.1 mmol/L; P = 0.003) and low-density lipoprotein (LDL) cholesterol levels (3.9 +/- 1.4 vs 3.2 +/- 1.0 mmol/L; P = 0.013) were identified in 47 patients on prednisolone vs 141 receiving hydrocortisone at baseline and at follow-up (P = 0.005 and P = 0.006, respectively). HbA1c, high-density lipoprotein and triglyceride levels, body mass index, systolic and diastolic blood pressure and waist circumference were not significantly different. Conclusions: This is the first matched analysis of its kind. Significantly higher LDL levels in patients receiving prednisolone relative to hydrocortisone could predict a higher relative risk of cardiovascular disease in the former group.

Place, publisher, year, edition, pages
BIOSCIENTIFICA LTD , 2017. Vol. 6, no 1
Keyword [en]
primary adrenal insufficiency; secondary adrenal insufficiency; cardiovascular risk; low-density lipoprotein cholesterol; cholesterol
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-136188DOI: 10.1530/EC-16-0081ISI: 000394142300001PubMedID: 27864317OAI: oai:DiVA.org:liu-136188DiVA: diva2:1086623
Note

Funding Agencies|ViroPharma/Shire

Available from: 2017-04-03 Created: 2017-04-03 Last updated: 2017-04-25

Open Access in DiVA

fulltext(1409 kB)1 downloads
File information
File name FULLTEXT01.pdfFile size 1409 kBChecksum SHA-512
50bcdc2ef265bfc1a11d03d4d0ee61475701db2a7b14b99cac87e3a559adbbc7e49331b68240ec1a99e15e1f486ceb571afaa7d20e94615fe54b8bac74975a48
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Ekman, Bertil
By organisation
Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Endocrinology
In the same journal
Endocrine Connections
Surgery

Search outside of DiVA

GoogleGoogle Scholar
Total: 1 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 27 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf