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Could PANSS be a useful tool in the determining of the stages of schizophrenia? A clinically operational approach
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
Aristotle University of Thessaloniki, Greece.
Aristotle University of Thessaloniki, Greece.
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2017 (English)In: Journal of Psychiatric Research, ISSN 0022-3956, E-ISSN 1879-1379, Vol. 86, 66-72 p.Article in journal (Refereed) Published
Abstract [en]

Staging in schizophrenia might be an important approach for the better treatment and rehabilitation of patients. The purpose of this study was to empirically devise a staging approach in a sample of stabilized patients with schizophrenia. One hundred and seventy patients aged amp;gt;= 18 years (mean = 40.7, SD = 11.6) diagnosed by DSM-5 criteria were evaluated with the Positive and Negative Syndrome Scale (PANSS). Principal components analysis (PCA) with varimax rotation was used. The model was examined in the total sample and separately across a hypothesized stage of illness based on three age groups and between the two sexes. The PCA revealed a six factor structure for the total sample: 1) Negative, 2) Positive, 3) Depression and anxiety, 4) Excitement and Hostility, 5) Neurocognition and 6) Disorganization. The separate PCAs by stage of illness and sex revealed different patterns and quality of symptomatology. The Negative and Positive factors were stable across all examined groups. The models corresponding to different stages differed mainly in terms of neurocognition and disorganization and their interplay. Catatonic features appear more prominent in males while in females neurocognition takes two forms; one with disorganization and one with stereotype thinking with delusions. This study suggests that the three arbitrary defined stages of illness (on the basis of age) seem to reflect a progress from a preserved insight and more coherent mental functioning to disorganization and eventually neurocognitive impairment. Sexes differ in terms of the relationship of psychotic features with neurocognition. These results might have significant research and clinical implications. (C) 2016 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2017. Vol. 86, 66-72 p.
Keyword [en]
Schizophrenia; Symptoms; Pyramidal model; Staging; Evaluation; PANSS
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:liu:diva-136163DOI: 10.1016/j.jpsychires.2016.11.013ISI: 000394072700010PubMedID: 27940386OAI: oai:DiVA.org:liu-136163DiVA: diva2:1086669
Available from: 2017-04-03 Created: 2017-04-03 Last updated: 2017-04-03

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Dragioti, ElenaWiklund, Tobias
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Division of Community MedicineFaculty of Medicine and Health SciencesDepartment of Medical and Health SciencesPain and Rehabilitation Center
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