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Oxygen saturation estimation in brain tissue using diffuse reflectance spectroscopy along stereotactic trajectories
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery.
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-0012-7867
2017 (English)In: Optics Express, ISSN 1094-4087, E-ISSN 1094-4087, Vol. 25, no 7, 8192-8201 p.Article in journal (Refereed) Published
Abstract [en]

Diffuse reflectance spectroscopy (DRS) can be used to estimate oxygen saturation (SO2) of hemoglobin and blood fraction (fB) in brain tissue. The aim of the study was to investigate the SO2 and fB in different positions along deep brain stimulation (DBS) trajectories and in specific target regions using DRS and a novel algorithm. DRS measurements were done at 166 well-defined anatomical positions in relation to stereotactic DBS-implantation along 20 trajectories toward 4 DBS targets (STN, Vim, GPi and Zi). The measurements were dived into groups (gray, white and light gray matter) related to anatomical position, and DBS targets, before comparison and statistical analysis. The median SO2 in gray, white and light gray matter were 52%, 24% and 20%, respectively. Median fB in gray matter (3.9%) was different from values in white (1.0%, p < 0.05) and light gray (0.9%, p < 0.001) matter. No significant difference in median SO2 and fB was found between DBS target regions. The novel algorithm allows for quick and reliable estimation of SO2 and fB in human brain tissue.

Place, publisher, year, edition, pages
Optical Society of America, 2017. Vol. 25, no 7, 8192-8201 p.
National Category
Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:liu:diva-136435DOI: 10.1364/OE.25.008192ISI: 000398536000094PubMedID: 28380934OAI: oai:DiVA.org:liu-136435DiVA: diva2:1087710
Note

Funding agencies: Swedish Research Council [621-2010-4216]; Swedish Childhood Cancer Foundation [MT2012-0043]; ALF Grant, Region Ostergotland

Available from: 2017-04-10 Created: 2017-04-10 Last updated: 2017-04-28Bibliographically approved

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Rejmstad, PeterZsigmond, PeterWårdell, Karin
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Division of Biomedical EngineeringFaculty of Science & EngineeringDivision of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of NeurosurgeryCenter for Medical Image Science and Visualization (CMIV)
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Optics Express
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