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Identification of Objective Morphometric Markers of Xerostomia in the Oral Mucosa Epithelium with In Vivo Confocal Microscopy
University of Oslo, Norway; Norwegian Dry Eye Clin, Norway.
Norwegian Dry Eye Clin, Norway; Oslo University Hospital, Norway.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping.
Harvard Medical Sch, MA 02114 USA.
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2017 (English)In: Microscopy and Microanalysis, ISSN 1431-9276, E-ISSN 1435-8115, Vol. 23, no 1, 88-96 p.Article in journal (Refereed) Published
Abstract [en]

The purpose of this work was to determine whether the morphology of the oral mucosa epithelium (OME) of patients with xerostomia differ from patients without xerostomia. In total, 34 patients with dry eye disease (DED) with or without xerostomia were examined at The Norwegian Dry Eye Disease Clinic with in vivo confocal microscopy of the lower lip. In addition, age- and gender-matched healthy controls (HC) were included. DED patients with xerostomia had a higher superficial to deep backscatter ratio compared with DED patients without xerostomia (p=0.002) and HC (p=0.001). Regression analysis demonstrated that this ratio was related to xerostomia independently of gender and age (pamp;lt;0.001). Sensitivity and specificity of detecting xerostomia were 0.78 and 0.85, respectively, when using a superficial to deep backscatter ratio cut-off value of 0.995 (p=0.004). The mean nucleus to cytosol backscatter ratio in the superficial OME was lower in patients with xerostomia than in those without xerostomia (p=0.034). In vivo confocal microscopy is a potential tool for evaluating the oral cavity and to assess changes in the OME associated with xerostomia, objectively and quantitatively. The cause of the increased backscatter in the superficial OME in xerostomia, however, remains to be elucidated.

Place, publisher, year, edition, pages
CAMBRIDGE UNIV PRESS , 2017. Vol. 23, no 1, 88-96 p.
Keyword [en]
xerostomia; dry mouth; in vivo confocal microscopy; oral mucosa epithelium
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-136339DOI: 10.1017/S1431927617000022ISI: 000395466500009PubMedID: 28162126OAI: oai:DiVA.org:liu-136339DiVA: diva2:1087903
Note

Funding Agencies|Department of Oral Biology, Faculty of Dentistry, University of Oslo

Available from: 2017-04-10 Created: 2017-04-10 Last updated: 2017-04-10

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Lagali, Neil
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Ophthalmology in Linköping
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