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Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. FISABIO Fdn, Spain; Spanish National Research Council, Spain.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
FISABIO Fdn, Spain.
Karolinska Institute, Sweden.
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2017 (English)In: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 139, no 3, 1017-+ p.Article in journal (Refereed) Published
Abstract [en]

Background: Although a reduced gut microbiota diversity and low mucosal total IgA levels in infancy have been associated with allergy development, IgA responses to the gut microbiota have not yet been studied. Objective: We sought to determine the proportions of IgA coating together with the characterization of the dominant bacteria, bound to IgA or not, in infant stool samples in relation to allergy development. Methods: A combination of flow cytometric cell sorting and deep sequencing of the 16S rDNA gene was used to characterize the bacterial recognition patterns by IgA in stool samples collected at 1 and 12 months of age from children staying healthy or having allergic symptoms up to 7 years of age. Results: The children with allergic manifestations, particularly asthma, during childhood had a lower proportion of IgA bound to fecal bacteria at 12months of age compared with healthy children. These alterations cannot be attributed to differences in IgA levels or bacterial load between the 2 groups. Moreover, the bacterial targets of early IgA responses (including coating of the Bacteroides genus), as well as IgA recognition patterns, differed between healthy children and children with allergic manifestations. Altered IgA recognition patterns in children with allergy were observed already at 1 month of age, when the IgA antibodies are predominantly maternally derived in breast-fed children. Conclusion: An aberrant IgAresponsiveness to the gutmicrobiota during infancy precedes asthma and allergy development, possibly indicating an impaired mucosal barrier function in allergic children.

Place, publisher, year, edition, pages
MOSBY-ELSEVIER , 2017. Vol. 139, no 3, 1017-+ p.
Keyword [en]
Allergic disease; asthma; secretory IgA; IgA index; IgA recognition patterns; microbiome composition; gut microbiota; childhood
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-136301DOI: 10.1016/j.jaci.2016.06.047ISI: 000397295800033PubMedID: 27531072OAI: oai:DiVA.org:liu-136301DiVA: diva2:1087982
Note

Funding Agencies|Swedish Research Council [K2011-56X-21854-01-06]; Swedish Heart-Lung Foundation [20140321]; Ekhaga Foundation [210-53]; Medical Research Council of Southeast Sweden; Olle Engqvist Foundation; Cancer and Allergy Foundation; University Hospital of Linkoping, Sweden; Spanish MINECO [2012-40007]

Available from: 2017-04-10 Created: 2017-04-10 Last updated: 2017-04-27

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Dzidic, MajdaAbrahamsson, ThomasJenmalm, Maria
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDivision of Children's and Women's healthDepartment of Paediatrics in Linköping
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Journal of Allergy and Clinical Immunology
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