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A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training
Linköping University, Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences.
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, USA.
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, USA.
Linköping University, Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Psychiatry.
2017 (English)In: Journal of Visualized Experiments, ISSN 1940-087X, E-ISSN 1940-087X, no 119, e53305Article in journal (Refereed) Published
Abstract [en]

Operant oral self-administration methods are commonly used to study the reinforcing properties of ethanol in animals. However, the standard methods require saccharin/sucrose fading, water deprivation and/or extended training to initiate operant responding in rats. This paper describes a novel and efficient method to quickly initiate operant responding for ethanol that is convenient for experimenters and does not require water deprivation or saccharin/sucrose fading, thus eliminating the potential confound of using sweeteners in ethanol operant self-administration studies. With this method, Wistar rats typically acquire and maintain self-administration of a 20% ethanol solution in less than two weeks of training. Furthermore, blood ethanol concentrations and rewards are positively correlated for a 30 min self-administration session. Moreover, naltrexone, an FDA-approved medication for alcohol dependence that has been shown to suppress ethanol self-administration in rodents, dose-dependently decreases alcohol intake and motivation to consume alcohol for rats self-administering 20% ethanol, thus validating the use of this new method to study the reinforcing properties of alcohol in rats.

Place, publisher, year, edition, pages
JOURNAL OF VISUALIZED EXPERIMENTS , 2017. no 119, e53305
Keyword [en]
Behavior; Issue 119; ethanol; self-administration; oral; reinforcement; animal model; addiction
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:liu:diva-136675DOI: 10.3791/53305ISI: 000397847200001PubMedID: 28190044OAI: oai:DiVA.org:liu-136675DiVA: diva2:1089738
Note

Funding Agencies|Swedish Research Council

Available from: 2017-04-20 Created: 2017-04-20 Last updated: 2017-05-23

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Augier, EricHeilig, Markus
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Center for Social and Affective NeuroscienceFaculty of Medicine and Health SciencesDepartment of Psychiatry
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CiteExportLink to record
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