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Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure ( COPE): A Pilot Study in Alcohol-dependent Women
Karolinska Institute, Sweden; Stockholm Centre Dependency Disorders, Sweden.
Medical University of South Carolina, USA; Ralph H Johnson Vet Affairs VA Medical Centre, SC USA.
Medical University of South Carolina, SC 29425 USA.
Medical University of South Carolina, SC 29425 USA; Ralph H Johnson Vet Affairs VA Medical Centre, SC USA.
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2017 (English)In: Journal of addiction medicine, ISSN 1932-0620, E-ISSN 1935-3227, Vol. 11, no 2, 119-125 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: Posttraumatic stress disorder (PTSD) and substance use disorders are highly comorbid. Effective treatments are largely lacking. This pilot study evaluated the safety and feasibility of a novel intervention, Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE), in preparation for a randomized controlled trial. Methods: Twenty-two treatment-seeking women with current DSM-IV-TR PTSD and alcohol dependence (AD) were recruited. Participants received COPE. Safety and feasibility were evaluated, as were efficacy-related outcomes: PTSD and depression symptom severity, alcohol use, craving, and dependence severity. Results: No adverse events occurred. COPE was implemented in routine clinical practice. Among the assessed women, 95.8% were eligible to participate. Treatment attendance and completion were higher than in previous studies. Post treatment, all efficacy-related outcomes, including PTSD and depression symptom severity, alcohol use, craving, and dependence severity, were significantly reduced. Conclusions: COPE was safe and feasible to use. Concerns that trauma-focused, exposure-based therapy might promote relapse in this population appear unwarranted. Our findings provide initial evidence suggestive of COPE efficacy for comorbid PTSD and AD in women. These results provide a strong rationale for investigating the efficacy of COPE for comorbid PTSD and AD in women in a randomized controlled trial.

Place, publisher, year, edition, pages
LIPPINCOTT WILLIAMS & WILKINS , 2017. Vol. 11, no 2, 119-125 p.
Keyword [en]
alcohol dependence; alcohol use disorder; integrated treatment; PTSD; women
National Category
Substance Abuse
Identifiers
URN: urn:nbn:se:liu:diva-136635DOI: 10.1097/ADM.0000000000000286ISI: 000397594900009PubMedID: 28079572OAI: oai:DiVA.org:liu-136635DiVA: diva2:1089849
Note

Funding Agencies|Swedish Society of Addiction Medicine; Systembolagets Alcohol Research Council; Soderstrom-Konigska Foundation

Available from: 2017-04-21 Created: 2017-04-21 Last updated: 2017-05-23

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Heilig, Markus
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Center for Social and Affective NeuroscienceFaculty of Medicine and Health SciencesDepartment of Psychiatry
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CiteExportLink to record
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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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More styles
Language
  • de-DE
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More languages
Output format
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