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Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences. CRUK, England; Institute Cancer Research, England; Institute Cancer Research, England; Royal Marsden NHS Fdn Trust, England.
CRUK, England; Institute Cancer Research, England; Kings Coll London, England.
CRUK, England; Institute Cancer Research, England; Institute Cancer Research, England; Royal Marsden NHS Fdn Trust, England; Kings Coll London, England; UCL, England.
University of Copenhagen, Denmark.
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2017 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 165Article in journal (Refereed) Published
Abstract [en]

The objective of this study was to evaluate the potential value of ultrasound (US) shear wave elastography (SWE) in assessing the relative change in elastic modulus in colorectal adenocarcinoma xenograft models in vivo and investigate any correlation with histological analysis. We sought to test whether non-invasive evaluation of tissue stiffness is indicative of pathological tumour changes and can be used to monitor therapeutic efficacy. US-SWE was performed in tumour xenografts in 15 NCr nude immunodeficient mice, which were treated with either the cytotoxic drug, Irinotecan, or saline as control. Ten tumours were imaged 48 hours post-treatment and five tumours were imaged for up to five times after treatment. All tumours were harvested for histological analysis and comparison with elasticity measurements. Elastic (Youngs) modulus prior to treatment was correlated with tumour volume (r = 0.37, p = 0.008). Irinotecan administration caused significant delay in the tumour growth (p = 0.02) when compared to control, but no significant difference in elastic modulus was detected. Histological analysis revealed a significant correlation between tumour necrosis and elastic modulus (r = -0.73, p = 0.026). SWE measurement provided complimentary information to other imaging modalities and could indicate potential changes in the mechanical properties of tumours, which in turn could be related to the stages of tumour development.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2017. Vol. 7, article id 165
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-136597DOI: 10.1038/s41598-017-00144-5ISI: 000396869100013PubMedID: 28279018OAI: oai:DiVA.org:liu-136597DiVA, id: diva2:1089973
Note

Funding Agencies|Institute of Cancer Research; Engineering and Physical Sciences Research Council; Cancer Research UK Cancer Imaging Centre at the Institute of Cancer Research; NHS

Available from: 2017-04-21 Created: 2017-04-21 Last updated: 2017-05-08

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