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Monocyte subsets in myocardial infarction: A review
Linköping University, Faculty of Medicine and Health Sciences. Wilhelminen Hospital, Austria.
Linköping University, Faculty of Medicine and Health Sciences. Wilhelminen Hospital, Austria.
Wilhelminen Hospital, Austria.
Medical University of Vienna, Austria.
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2017 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 231, 47-53 p.Article, review/survey (Refereed) Published
Abstract [en]

Background: Monocytes form an important part of the human innate immune system by taking part in inflammatory reactions. With time, monocytes have gained interest in the role they may play during the event of myocardial infarction (MI). The current paradigm suggests that monocytes consist of three subdivisions which differ in phenotypic and dynamic patterns after an MI. In the inflammation that ensues, the different subsets have been shown to have an impact on reparative processes and patient recovery. Methods results: We searched Medline and Embase until April 5, 2016, for observational studies or clinical trials regarding monocyte functions and dynamics in MI. Apart from studies in humans, extensive work has been done in mice in an effort to understand the complex nature of monocyte dynamics. Animal models might add useful information on mapping these processes. Conclusion: The question still remains whether animal data can, to a certain degree, be extrapolated to monocyte functions during human MI. This review aims to summarize current available evidence on both mice and men with particular focus on the understanding of monocyte subsets dynamics and effects in human MI. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD , 2017. Vol. 231, 47-53 p.
Keyword [en]
Monocyte subsets; Myocardial infarction; Cardiovascular disease
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-136588DOI: 10.1016/j.ijcard.2016.12.182ISI: 000397905600009PubMedID: 28062145OAI: oai:DiVA.org:liu-136588DiVA: diva2:1089990
Note

Funding Agencies|Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna, Austria; Association for the Promotion of Research in Arteriosclerosis, Thrombosis and Vascular Biology (ATVB)

Available from: 2017-04-21 Created: 2017-04-21 Last updated: 2017-05-01

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CiteExportLink to record
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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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  • Other style
More styles
Language
  • de-DE
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More languages
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