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Exercise testing for long-term follow-up in arrhythmogenic right ventricular cardiomyopathy
Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
2017 (English)In: Journal of Electrocardiology, ISSN 0022-0736, E-ISSN 1532-8430, Vol. 50, no 2, 176-183 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: We investigated arrhythmia, electrocardiography and physical work capacity (PWC) in the follow-up of ARVC. Design: Twenty-three patients (13 men; age 41 +/- 12 years) fulfilling diagnostic criteria were re-investigated after at least five years. Results: Ventricular arrhythmia during exercise testing (ET) was present in 14 patients (61%) and showed variation between examinations. In eleven (48%), complex ventricular ectopic activity was observed at peak exercise or immediately thereafter. Mutations known to be pathogenic in ARVC were present in 13 patients (57%) of which 11 developed complex ventricular arrhythmia at ET. PWC at baseline was 190 +/- 66 W (104 +/- 26%) decreasing to 151 +/- 61 W (91 +/- 23%, p = 0.008) after 10.7 years. Conclusion: The appearance of ventricular arrhythmia during exercise testing showed temporal variation but was.frequent in patients with relevant genetic mutation. Physical exercise capacity decreased over time in patients with ARVC in excess to the age-related deterioration and regardless of medication. (C) 2016 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
Churchill Livingstone , 2017. Vol. 50, no 2, 176-183 p.
Keyword [en]
ARVC; Exercise testing; Arrhythmia; Follow up
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-136755DOI: 10.1016/j.jelectrocard.2016.10.011ISI: 000397368100002PubMedID: 28012557ScopusID: 2-s2.0-85008157736OAI: oai:DiVA.org:liu-136755DiVA: diva2:1090688
Note

Funding Agencies|ALF Grants, Region Ostergotland, Sweden

Available from: 2017-04-25 Created: 2017-04-25 Last updated: 2017-04-28Bibliographically approved

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Karlsson, DanielEngvall, JanAlfoldine Ando, AgotaÅstrom Aneq, Meriam
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Department of Clinical Physiology in LinköpingDepartment of Medical and Health SciencesFaculty of Medicine and Health SciencesDivision of Cardiovascular Medicine
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Journal of Electrocardiology
Cardiac and Cardiovascular Systems

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