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Rational Design of a Conductive Collagen Heart Patch
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. (Biomaterials and Tissue Engineering)
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Institute of Automatic Control, Silesian University of Technology, Gliwice, Poland.
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Medicine and Health Sciences.
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2017 (English)In: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 17, no 7, 1600446Article in journal, Editorial material (Refereed) Published
Abstract [en]

Cardiovascular diseases, including myocardial infarction, are the cause of significant morbidity and mortality globally. Tissue engineering is a key emerging treatment method for supporting and repairing the cardiac scar tissue caused by myocardial infarction. Creating cell supportive scaffolds that can be directly implanted on a myocardial infarct is an attractive solution. Hydrogels made of collagen are highly biocompatible materials that can be molded into a range of shapes suitable for cardiac patch applications. The addition of mechanically reinforcing materials, carbon nanotubes, at subtoxic levels allows for the collagen hydrogels to be strengthened, up to a toughness of 30 J m-1 and a two to threefold improvement in Youngs' modulus, thus improving their viability as cardiac patch materials. The addition of carbon nanotubes is shown to be both nontoxic to stem cells, and when using single-walled carbon nanotubes, supportive of live, beating cardiac cells, providing a pathway for the further development of a cardiac patch.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2017. Vol. 17, no 7, 1600446
Keyword [en]
Carbon nanotube, Collagen, Hydrogel, Myocardial infarction, Stem cell
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-136817DOI: 10.1002/mabi.201600446ISI: 000405566300004PubMedID: 28322510Scopus ID: 2-s2.0-85016390421OAI: oai:DiVA.org:liu-136817DiVA: diva2:1091634
Note

Funding agencies: Linkoping Initiative in Life Science Technologies (LIST); Central ALF Matching Grant from Landstinget i Ostergotland [LIO-344071]; European Research Agency [304209]; GeCONiI [POIG.02.03.01-24-099/13]

Available from: 2017-04-27 Created: 2017-04-27 Last updated: 2017-08-09Bibliographically approved

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Sherrell, PeterCieślar-Pobuda, ArturSilverå Ejneby, MalinSammalisto, LauraGelmi, Amyde Muinck, EboBrask, JohanJan Los, MarekRafat, Mehrdad
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Department of Biomedical EngineeringFaculty of Science & EngineeringDivision of Cell BiologyFaculty of Medicine and Health SciencesDivison of NeurobiologyDepartment of Physics, Chemistry and BiologyDivision of Cardiovascular MedicineDepartment of Cardiology in Linköping
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