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Systemic alterations in plasma proteins from women with chronic widespread pain compared to healthy controls: a proteomic study
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
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2017 (English)In: Journal of Pain Research, ISSN 1178-7090, E-ISSN 1178-7090, Vol. 10, 797-809 p.Article in journal (Refereed) Published
Abstract [en]

Chronic widespread pain (CWP) is a complex pain condition that is difficult to treat. The prevalence of CWP approximates similar to 10% of the general population, with higher prevalence in women. Lack of understanding of molecular mechanisms has been a challenge for diagnosis and treatment of chronic pain. The aim of this study was to explore the systemic protein changes in CWP compared to those in healthy controls (CON). By applying 2-dimensional gel electrophoresis, we analyzed the protein pattern of plasma samples from women with CWP (n=16) and healthy women (n=23). The proteomic data were analyzed using multivariate statistical models, and altered proteins were identified using mass spectrometry. The proteome analysis was further validated by gel-free Western blot. Multivariate statistical data analysis of quantified proteins revealed 22 altered proteins in women with CWP, compared to CON group. Many of the identified proteins are previously known to be involved in different parts of the complement system and metabolic and inflammatory processes, e.g., complement factor B, vitamin D-binding protein, ceruloplasmin, transthyretin and alpha-2-HS-glycoprotein. These results indicate that important systemic protein differences exist between women with CWP and healthy women. Further, this study illustrates the potential use of proteomics to detect biomarkers that may provide new insights into the molecular mechanism(s) of chronic pain. However, further larger investigations are required in order to confirm these findings before it will be possible to identify proteins as potential pain biomarkers for clinical use.

Place, publisher, year, edition, pages
DOVE MEDICAL PRESS LTD , 2017. Vol. 10, 797-809 p.
Keyword [en]
inflammation; biomarker; painomics; complement system; GC protein
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:liu:diva-136895DOI: 10.2147/JPR.S128597ISI: 000398611900001PubMedID: 28435317OAI: oai:DiVA.org:liu-136895DiVA: diva2:1092059
Note

Funding Agencies|Swedish Council for Working Life and Social Research [2010-0913]; Swedish Research Council [K2015-99X-21874-05-04]; Medical Research Council of Southeast Sweden [159031]; AFA Insurance [Dnr-140341]; Region Ostergotland research fund [LIO445161, SC-2013-00395-36]; Ake Wiberg foundation

Available from: 2017-04-29 Created: 2017-04-29 Last updated: 2017-05-21

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Wåhlén, KarinOlausson, PatrikCarlsson, AndersGhafouri, NazdarGerdle, BjörnGhafouri, Bijar
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CiteExportLink to record
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