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Oral immunoglobulin treatment improved intestinal permeability in children with active Crohns disease
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Norrköping.
Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Norrköping. Karolinska Institute, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
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2017 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, no 4, 647-653 p.Article in journal (Refereed) Published
Abstract [en]

Aim: Crohns disease (CD) is a chronic mucosal inflammation that affects the intestinal barrier function, for example, by altering the intestinal permeability. This pilot clinical study investigated the impact of oral human immunoglobulin (OHIG) treatment on permeability characteristics in children with active luminal Crohns disease. Methods: The study was performed at the Department of Paediatrics, Norrkoping Hospital, Sweden. Intestinal permeability was studied in three boys aged 13, 15 and 18 years with active CD, before and after a six-week treatment programme with OHIG, using different-sized polyethylene glycols as the test molecules. Three age-and sex-matched children with active CD treated with exclusive enteral nutrition (EEN) were also studied. Results: OHIG and EEN resulted in virtually similar reductions in the signs and symptoms of mucosal inflammation. However, OHIG, unlike EEN, appeared to normalise mucosal transfer leading to a normalisation of the maximum permeation of the small PEG molecules, as well as less restrictions of the larger PEG molecules. Conclusion: Our study found that OHIG appeared to normalise the mucosal barrier. This suggests that it could offer a new additional and versatile treatment for paediatric CD patients, with a minimal risk of adverse effects.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 106, no 4, 647-653 p.
Keyword [en]
Crohns disease; Exclusive enteral nutrition; Intestinal permeability; Oral immunoglobulin treatment; Polyethylene glycols
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-136868DOI: 10.1111/apa.13747ISI: 000397511300021PubMedID: 28107568OAI: oai:DiVA.org:liu-136868DiVA: diva2:1092105
Note

Funding Agencies|Bayer AG; County Council of Ostergotland, Sweden

Available from: 2017-04-30 Created: 2017-04-30 Last updated: 2017-04-30

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Sundqvist, TommyStenhammar, LarsMagnusson, Karl-EricForslund, TonyHögberg, Lotta
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Division of Clinical SciencesFaculty of Medicine and Health SciencesDivision of Children's and Women's healthDepartment of Paediatrics in NorrköpingDivision of Microbiology and Molecular Medicine
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CiteExportLink to record
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