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Cut thy neighbor: cyclic birth and death of recombination hotspots via genetic conflict.
Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, California, USA.ORCID iD: 0000-0001-6112-9586
Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, California, USA.
2008 (English)In: Genetics, ISSN 0016-6731, E-ISSN 1943-2631, Vol. 179, no 4, 2229-2238 p.Article in journal (Refereed) Published
Abstract [en]

Most recombination takes place in numerous, localized regions called hotspots. However, empirical evidence indicates that nascent hotspots are susceptible to removal due to biased gene conversion, so it is paradoxical that they should be so widespread. Previous modeling work has shown that hotspots can evolve due to genetic drift overpowering their intrinsic disadvantage. Here we synthesize recent theoretical and empirical results to show how natural selection can favor hotspots. We propose that hotspots are part of a cycle of antagonistic coevolution between two tightly linked chromosomal regions: an inducer region that initiates recombination during meiosis by cutting within a nearby region of DNA and the cut region itself, which can evolve to be resistant to cutting. Antagonistic coevolution between inducers and their cut sites is driven by recurrent episodes of Hill-Robertson interference, genetic hitchhiking, and biased gene conversion.

Place, publisher, year, edition, pages
Genetics Society of America , 2008. Vol. 179, no 4, 2229-2238 p.
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:liu:diva-137230DOI: 10.1534/genetics.107.085563PubMedID: 18689896OAI: oai:DiVA.org:liu-137230DiVA: diva2:1094287
Available from: 2017-05-09 Created: 2017-05-09 Last updated: 2017-05-09Bibliographically approved

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