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Long-term effects on the incidence of second primary cancers in a randomized trial of two and five years of adjuvant tamoxifen
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Health and Developmental Care, Regional Cancer Center South East Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
Umeå University Hospital, Sweden.
Karolinska University Hospital, Sweden.
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2017 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 56, no 4, 614-617 p.Article in journal (Refereed) Published
Abstract [en]

Background: Tamoxifen is a well established treatment for breast cancer, but its long-term effects on the incidence of secondary cancers are not fully evaluated.Material and methods: We have studied 4128 postmenopausal patients with early stage breast cancer who were alive and free of breast cancer recurrence after two years of tamoxifen, and who were randomized to receive totally two or five years of therapy.Results: Compared to patients randomized to two years of tamoxifen the incidence of contralateral breast cancer [hazard ratio (HR) 0.73; 95% CI 0.56-0.96] and of lung cancer (HR 0.45; 95% CI 0.27-0.77), especially squamous cell and small cell lung cancer, were reduced in the five-year group, and similar results were seen when restricting the analysis to the 10-year period after treatment stopped. An increased incidence of endometrial cancer was observed in the five-year group, but the excess risk decreased over time.Conclusion: Further studies of the effects of tamoxifen on the risk of different histological types of lung cancer are needed.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2017. Vol. 56, no 4, 614-617 p.
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Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-137409DOI: 10.1080/0284186X.2016.1273547ISI: 000399499600016PubMedID: 28080180OAI: oai:DiVA.org:liu-137409DiVA: diva2:1096660
Available from: 2017-05-18 Created: 2017-05-18 Last updated: 2017-05-18

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Rosell, JohanNordenskjöld, BoStål, OlleCarstensen, John
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Division of Clinical SciencesFaculty of Medicine and Health SciencesRegional Cancer Center South East SwedenDivision of Surgery, Orthopedics and OncologyDepartment of OncologyDivision of Health Care AnalysisFaculty of Arts and Sciences
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CiteExportLink to record
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