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Venous thrombosis in children and adolescents with Hodgkin lymphoma in Sweden
Karolinska University Hospital, Sweden; Karolinska Institute, Sweden.
Karolinska University Hospital, Sweden; Karolinska Institute, Sweden.
Karolinska University Hospital, Sweden; Karolinska Institute, Sweden.
Karolinska University Hospital, Sweden; Karolinska Institute, Sweden.
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2017 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 152, 64-68 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: Pediatric patients with Hodgkin lymphoma (HL) have several risk factors for venous thromboembolism (VTE). Although these patients are occasionally treated with thromboprophylaxis, no guidelines are implemented in Sweden. Scarce data from adult patients indicate an increased risk of VTE, but pediatric data is largely missing. Given the favorable overall survival of HL, there should reasonably be more focus on preventing complications. Materials and ethods: We conducted a retrospective cohort study, including all patients registered in the Childhood Cancer Registry under the age of 18 years diagnosed with HL between January 2005 and December 2015 in Sweden. Results: Data was retrieved from the medical records of all 163 patients (100%) at six Swedish pediatric cancer centers. The incidence of VTE was 7.7% (symptomatic VTE 3.9%). The median follow-up was 3.4 years (range 0.3-10.5). Only five patients (3.1%) were treated with thromboprophylaxis. All VTE events occurred in the older age category (11-17 years) and all but one (92.7%) had a mediastinal mass. While the VTE did not significantly affect the treatment of HL, it caused increased morbidity and 2/12 developed a post-thrombotic syndrome. No significant risk factors for VTE were identified. Conclusions: VTE is a relatively common complication of HL and its treatment, causing increased acute and long-term morbidity. However, due to limited number of events we could not demonstrate risk-factors for VTE that would identify patients who might benefit from thromboprophylaxis. (C) 2017 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2017. Vol. 152, 64-68 p.
Keyword [en]
Hodgkin lymphoma; Venous thromboembolism; Children; Adolescents
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-137404DOI: 10.1016/j.thromres.2017.02.011ISI: 000399245600013PubMedID: 28249199OAI: oai:DiVA.org:liu-137404DiVA: diva2:1096666
Note

Funding Agencies|Swedish Childhood Cancer Foundation, Sweden [AHS KF2010-0005, MH OI2014-0001, IO KF2015-008, SR TJ2016-0018]

Available from: 2017-05-18 Created: 2017-05-18 Last updated: 2017-05-18

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Holmqvist Persson, Britt-Marie
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Division of Clinical SciencesFaculty of Health SciencesDepartment of Paediatrics in Linköping
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CiteExportLink to record
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Cite
Citation style
  • apa
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More styles
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