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Synthesis and identification of an important metabolite of AKB-48 with a secondary hydroxyl group on the adamantyl ring
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
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2017 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1359-8562, Vol. 58, no 15, 1456-1458 p.Article in journal (Refereed) Published
Abstract [en]

Studies on the metabolism of bioactive substances containing the adamantyl moiety have shown that hydroxylation is likely to occur at a tertiary carbon of adamantane. Herein, we report the synthesis and identification of one major metabolite of AKB-48, a new illicit psychoactive substance with a hydroxyl group at a secondary carbon of the adamantyl ring. (C) 2017 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2017. Vol. 58, no 15, 1456-1458 p.
Keyword [en]
Admantane; AKB-48; Synthetic cannabinoid; Metabolite; Biomarker
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-137391DOI: 10.1016/j.tetlet.2017.02.077ISI: 000399517600008OAI: oai:DiVA.org:liu-137391DiVA: diva2:1096683
Note

Funding Agencies|National Board of Forensic Medicine in Sweden

Available from: 2017-05-18 Created: 2017-05-18 Last updated: 2017-06-14

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The full text will be freely available from 2019-02-27 14:42
Available from 2019-02-27 14:42

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Wallgren, JakobVikingsson, SvanteJohansson, AndersJosefsson, MartinGreen, HenrikDahlén, JohanWu, XiongyuKonradsson, Peter
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ChemistryFaculty of Science & EngineeringDivision of Drug ResearchFaculty of Medicine and Health SciencesDepartment of Physics, Chemistry and Biology
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Tetrahedron Letters
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CiteExportLink to record
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