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Modeling of the mechanobiological adaptation in muscular arteries
Linköping University, Department of Management and Engineering, Solid Mechanics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-1503-8293
Linköping University, Department of Management and Engineering, Solid Mechanics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Management and Engineering, Solid Mechanics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-8460-0131
2017 (English)In: European journal of mechanics. A, Solids, ISSN 0997-7538, E-ISSN 1873-7285, Vol. 64, 165-177 p.Article in journal (Refereed) Published
Abstract [en]

The growth and remodeling of arteries, as controlled by the local stress state and the sensory input from the endothelial cells of the artery wall, is given a novel theoretical framework incorporating the active behavior of vascular smooth muscle. We show that local sensory input maps uniquely to the ratio between a target arterial wall cross-section area corresponding to homeostatic conditions and the current arterial wall area. A growth law is formulated by taking the production rates of individual constituents of the arterial wall to be functions of this target-to-current wall area ratio. We find that a minimum active stress response of vascular smooth muscle is necessary to achieve stable adaptation of the artery wall to dynamic flow conditions. With a sufficient active stress alteration in response to stretch, stable growth toward a homeostatic state can be observed for finite step changes or ramp changes in the transmural pressure or the flow rate. (C) 2017 Elsevier Masson SAS. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2017. Vol. 64, 165-177 p.
Keyword [en]
Arterial adaptation; Finite elasticity; Growth; Remodeling
National Category
Applied Mechanics
Identifiers
URN: urn:nbn:se:liu:diva-137371DOI: 10.1016/j.euromechsol.2017.01.011ISI: 000399515700013OAI: oai:DiVA.org:liu-137371DiVA: diva2:1096708
Note

Funding Agencies|Swedish Research Council [621-2012-3117]

Available from: 2017-05-18 Created: 2017-05-18 Last updated: 2017-06-07

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The full text will be freely available from 2019-01-31 15:31
Available from 2019-01-31 15:31

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Lindström, StefanStålhand, JonasKlarbring, Anders
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