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Circulating cartilage oligomeric matrix protein in juvenile idiopathic arthritis
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-6916-5490
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2017 (English)In: Scandinavian Journal of Rheumatology, ISSN 0300-9742, E-ISSN 1502-7732, Vol. 46, no 3, 194-197 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: Raised serum cartilage oligomeric matrix protein (sCOMP) has been reported to predict erosive disease in early rheumatoid arthritis (RA). In juvenile idiopathic arthritis (JIA), subnormal sCOMP levels have been associated with ongoing inflammation and growth retardation. In this study we aimed to assess sCOMP, C-reactive protein (CRP), and insulin-like growth factor (IGF)-1 in children/adolescents with JIA and in referents.Method: We enrolled 52 JIA patients at planned outpatient visits and 54 inpatients with ongoing infection (infection referents). A total of 120 referents testing negative for immunoglobulin (Ig)E-mediated allergy (IgE referents) served as controls. All serum samples were analysed for COMP, IGF-1, and CRP.Results: The average sCOMP level was highest among the IgE referents and lowest among the infection referents. In the JIA patients, the level of sCOMP was not associated with the level of CRP or with clinical signs of disease activity.Conclusions: The results of this study do not support routine clinical analysis of sCOMP levels in patients with JIA.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2017. Vol. 46, no 3, 194-197 p.
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:liu:diva-137876DOI: 10.1080/03009742.2016.1192681ISI: 000400681100004PubMedID: 27385219OAI: oai:DiVA.org:liu-137876DiVA: diva2:1104986
Note

Funding Agencies|Swedish Rheumatism Association

Available from: 2017-06-02 Created: 2017-06-02 Last updated: 2017-07-06

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Lewander, PerDahle, CharlotteWetterö, JonasSkogh, Thomas
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Clinical Immunology and Transfusion MedicineDepartment of Clinical ChemistryDepartment of Rheumatology
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Scandinavian Journal of Rheumatology
Rheumatology and Autoimmunity

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