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Pre-clinical longitudinal monitoring of hemodynamic response to anti-vascular chemotherapy by hybrid diffuse optics
Barcelona Institute Science and Technology, Spain; Harvard Medical Sch, MA 02129 USA.
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Barcelona Institute Science and Technology, Spain.
Barcelona Institute Science and Technology, Spain.
Bellvitge Biomed Research Institute IDIBELL, Spain.
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2017 (English)In: Biomedical Optics Express, ISSN 2156-7085, E-ISSN 2156-7085, Vol. 8, no 5, 2563-2582 p.Article in journal (Refereed) Published
Abstract [en]

The longitudinal effect of an anti-vascular endothelial growth factor receptor 2 (VEGFR-2) antibody (DC 101) therapy on a xenografted renal cell carcinoma (RCC) mouse model was monitored using hybrid diffuse optics. Two groups of immunosuppressed male nude mice (seven treated, seven controls) were measured. Tumor microvascular blood flow, total hemoglobin concentration and blood oxygenation were investigated as potential biomarkers for the monitoring of the effect of therapy twice a week and were related to the final treatment outcome. These hemodynamic biomarkers have shown a clear differentiation between two groups by day four. Moreover, we have observed that pre-treatment values and early changes in hemodynamics are highly correlated with the therapeutic outcome demonstrating the potential of diffuse optics to predict the therapy response at an early time point. (C) 2017 Optical Society of America

Place, publisher, year, edition, pages
OPTICAL SOC AMER , 2017. Vol. 8, no 5, 2563-2582 p.
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-137845DOI: 10.1364/BOE.8.002563ISI: 000400500400013OAI: oai:DiVA.org:liu-137845DiVA: diva2:1105156
Note

Funding Agencies|Fundacio Cellex Barcelona, Marie Curie IEF (FP7 MOBODICT); Ministerio de Economia y Competitividad (PHOTODEMENTIA) [DPI2015-64358-C2-1-R, SAF2012-36575, RTICC RD2006-0092]; lObra Social La Caixa (LlumMedBCN); "Severo Ochoa" Programme for Centres of Excellence in RD [SEV-2015-0522]; ERC-FP7 [ERC-StG-281830]; AGAUR-Generalitat [2014-SGR725, 2014SGR-1555]; National Institutes of Health (NIH) [K99/R00-CA126187]

Available from: 2017-06-02 Created: 2017-06-02 Last updated: 2017-06-02

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CiteExportLink to record
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Citation style
  • apa
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