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NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. University of Athens, Greece.
Aghia Sophia Childrens Hospital, Greece.
Aghia Sophia Childrens Hospital, Greece.
University of Athens, Greece.
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2017 (English)In: Journal of Diabetes Research, ISSN 2314-6745, E-ISSN 2314-6753, 7526919Article in journal (Refereed) Published
Abstract [en]

Aims. Type 1 diabetes (T1D) is often associated with early microvascular complications. Previous studies demonstrated that increased systolic (SAP) and diastolic arterial blood pressures (DAP) are linked to microvascular morbidity in T1D. The aim of the study was to investigate the predictive role of neutrophil gelatinase-associated lipocalin (NGAL) in unravelling early cardiorenal dysfunction in T1D. Methods. Two T1D patient groups participating in two-centre prospective cohorts were studied. Group A consisted of 57 participants aged 13.9 years (SD: 3.1) and group B consisted of 59 patients aged 28.0 years (SD: 4.4). Forty-nine healthy children [age: 10.5 years (SD: 6.6)] and 18 healthy adults [age 27.7 years (SD: 4.2)] served as controls. Serum concentrations of NGAL (ELISA) were determined, and SAP and DAP were examined (SAP and DAP also expressed as z-scores in the younger group). Results. NGAL correlated positively with SAP in both patient groups (P = 0 020 and P = 0 031, resp.) and SAP z-score (P = 0 009) (group A) and negatively with eGFR in both groups (P amp;lt; 0 001 and P amp;lt; 0 001, resp.). Conclusions. NGAL may be proposed as a biomarker of early renal dysfunction even in nonalbuminuric T1D patients, since it was strongly associated with renal function decline and increasing systolic arterial pressure even at prehypertensive range in people with T1D, in a broad age range.

Place, publisher, year, edition, pages
HINDAWI LTD , 2017. 7526919
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-138299DOI: 10.1155/2017/7526919ISI: 000401938100001OAI: oai:DiVA.org:liu-138299DiVA: diva2:1109049
Available from: 2017-06-13 Created: 2017-06-13 Last updated: 2017-06-13

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Papadopoulou, NektariaWahlberg Topp, Jeanette
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Department of Medical and Health SciencesFaculty of Medicine and Health SciencesDivision of Cardiovascular MedicineDepartment of Endocrinology
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