liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Two-Photon Active Organotin(IV) Carboxylate Complexes for Visualization of Anticancer Action
Anhui University, Peoples R China.
Anhui University, Peoples R China.
Anhui University, Peoples R China.
Anhui University, Peoples R China.
Show others and affiliations
2017 (English)In: ACS BIOMATERIALS SCIENCE and ENGINEERING, ISSN 2373-9878, Vol. 3, no 5, 836-842 p.Article in journal (Refereed) Published
Abstract [en]

It is still a challenge that organotin(IV) carboxylate complexes with high-performance two-photon activity for cancer therapy. At present work, two novel organotin carboxylate complexes LSn1 and LSn2, containing coumarin moiety, were rationally designed for two-photon fluorescent imaging and anticancer purpose. The complexes possessed large two-photon action cross-sections and high quantum yields. Living cells evaluation revealed that complexes LSn1 and LSn2 exhibited good biocompatibility and deep tissue penetration over femtosecond laser with wavelength of 840 nm. Furthermore, the antitumor active and as well as possible mechanism of complexes LSn1 and LSn2 have been investigated systematically. The results indicated that complexes LSn1 and LSn2 could induce apoptotic cell death through a mitochondria] dysfunction and ROS elevation pathway. The present work provides a strategy for rationally designing organotin(IV) carboxylate complexes with two-photon activity and antitumor activity.

Place, publisher, year, edition, pages
AMER CHEMICAL SOC , 2017. Vol. 3, no 5, 836-842 p.
Keyword [en]
organotin carboxylate; two photon property; two-photon microscopy; anticancer agents; crystal structures
National Category
Medical Materials
Identifiers
URN: urn:nbn:se:liu:diva-138267DOI: 10.1021/acsbiomaterials.6b00786ISI: 000401053800019OAI: oai:DiVA.org:liu-138267DiVA: diva2:1109114
Note

Funding Agencies|National Natural Science Foundation of China [21602003, 51372003, 51672003, 51432001, 21501001, 51472002]; Ministry of Education; Higher Education Revitalization Plan Talent Project

Available from: 2017-06-13 Created: 2017-06-13 Last updated: 2017-06-13

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Hu, Zhang-Jun
By organisation
Molecular Surface Physics and Nano ScienceFaculty of Science & Engineering
Medical Materials

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 828 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf